Penicillin-induced disease in hamsters — latent-virus activation and endotoxin hypothesis (Green 1974, PMID 4446629)
Verbatim first-hand facts from the PubMed abstract of Green RH (Yale J Biol Med 1974;47(3):166-81), retrieved via NLM E-utilities efetch. All bullets are exact substrings of the cited source file (whitespace-normalised) and C1-substring verified. Focus: penicillin-induced disease in the pet hamster.
Toxicology facts
- A virus similar or identical to the guinea pig virus also has been isolated from hamsters dying of penicillin-induced disease.
- A virus having some of the properties of a parvovirus has been isolated repeatedly from animals ill or dying of penicillin-induced disease.
- It is hypothesized that the absorption of endotoxin, resulting from the well known change in intestinal flora caused by penicillin, produces a state of immunodeficiency which regularly gives rise to activation of a latent virus, and perhaps, rarely, to the development of malignant neoplasms.
Related: exotic_tox_guinea_pig_penicillin_syndromes (same source), exotic_tox_gerbil_penicillin.