{"topic_id":"exotic_tox_hamster_penicillin","category":"exotic-pet-toxicology","context":"---\ntopic_id: exotic_tox_hamster_penicillin\ncategory: exotic-pet-toxicology\ntitle: \"Penicillin-induced disease in hamsters — latent-virus activation and endotoxin hypothesis (Green 1974, PMID 4446629)\"\nlang: en\nsource: \"PubMed abstract PMID 4446629 — Yale J Biol Med 1974 Sep;47(3):166-81 (NLM E-utilities efetch, official API)\"\nsource_file: pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt\ndate_parsed: 2026-07-29\ntokens_estimated: 277\nverified: true\nverification: c1_substring\nsource_document: \"Yale Journal of Biology and Medicine 1974;47(3):166-81 (PubMed PMID 4446629)\"\ncitation:\n  authority: \"U.S. National Library of Medicine (PubMed)\"\n  title: \"The association of viral activation with penicillin toxicity in guinea pigs and hamsters (Green RH, Yale J Biol Med 1974;47(3):166-81)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/4446629/\"\n  retrieved: \"2026-07-29\"\n  ref: \"PMID 4446629\"\n  doc_type: \"official text extract\"\n  needs_review: false\n---\n\n# Penicillin-induced disease in hamsters — latent-virus activation and endotoxin hypothesis (Green 1974, PMID 4446629)\n\nVerbatim first-hand facts from the PubMed abstract of Green RH (Yale J Biol Med 1974;47(3):166-81), retrieved via NLM E-utilities efetch. All bullets are exact substrings of the cited source file (whitespace-normalised) and C1-substring verified. Focus: penicillin-induced disease in the pet hamster.\n\n## Toxicology facts\n\n- A virus similar or identical to the guinea pig virus also has been isolated from hamsters dying of penicillin-induced disease.\n- A virus having some of the properties of a parvovirus has been isolated repeatedly from animals ill or dying of penicillin-induced disease.\n- It is hypothesized that the absorption of endotoxin, resulting from the well known change in intestinal flora caused by penicillin, produces a state of immunodeficiency which regularly gives rise to activation of a latent virus, and perhaps, rarely, to the development of malignant neoplasms.\n\nRelated: `exotic_tox_guinea_pig_penicillin_syndromes` (same source), `exotic_tox_gerbil_penicillin`.\n","sources":["exotic-pet-toxicology — The association of viral activation with penicillin toxicity in guinea pigs and hamsters (Green RH, Yale J Biol Med 1974;47(3):166-81) (retrieved 2026-07-29)"],"source":{"authority":"exotic-pet-toxicology","title":"The association of viral activation with penicillin toxicity in guinea pigs and hamsters (Green RH, Yale J Biol Med 1974;47(3):166-81)","url":"https://pubmed.ncbi.nlm.nih.gov/4446629/","retrieved":"2026-07-29","ref":"PMID 4446629","doc_type":"official PDF","source_document":"Yale Journal of Biology and Medicine 1974;47(3):166-81 (PubMed PMID 4446629)","verification_file":"pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt"},"source_document":"Yale Journal of Biology and Medicine 1974;47(3):166-81 (PubMed PMID 4446629)","source_file":"pdf-raw/exotic-toxicology/pubmed_4446629_penicillin_guineapig_hamster.txt","tokens_estimated":277,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}