Penicillin toxicity syndromes in guinea pigs — toxic, hemorrhagic, chronic (Green 1974, PMID 4446629)
Verbatim first-hand facts from the PubMed abstract of Green RH, 'The association of viral activation with penicillin toxicity in guinea pigs and hamsters' (Yale J Biol Med 1974;47(3):166-81), retrieved via NLM E-utilities efetch. All bullets are exact substrings of the cited source file (whitespace-normalised; the 1974 abstract is printed in capitals) and C1-substring verified.
Toxicology facts
- The association of viral activation with penicillin toxicity in guinea pigs and hamsters.
- PENICILLIN TOXICITY IN THE GUINEA PIG MAY BE MANIFESTED IN SEVERAL DIFFERENT WAYS, AND IT IS PROPOSED THAT THESE TOXIC EFFECTS BE CATEGORIZED INTO THREE SYNDROMES: (1) toxic syndrome, characterized by acute fatal illness; (2) hemorrhagic syndrome, characterized by delayed illness with leukopenia and thrombocytopenia, and culminating in massive visceral hemorrhages; (3) chronic syndrome, characterized by retardation of growth and alopecia, a condition somewhat resembling "runt disease."
- Of some 60 guinea pigs which received injections of penicillin three developed tumors and four others were found to have gallstones.
- A virus having some of the properties of a parvovirus has been isolated repeatedly from animals ill or dying of penicillin-induced disease.
Related: exotic_tox_guinea_pig_penicillin (Merck), exotic_tox_hamster_penicillin.