Evidence: canine epilepsy: antiepileptic drug management (peer-reviewed, Europe PMC)
Source: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-24. Query: (canine epilepsy OR epileptic dog) AND (antiepileptic OR phenobarbital OR imepitoin OR management OR treatment). The cluster returns 6 first-hand abstracts extracted below (verbatim sentences, each traceable by PMID).
Verified claims (verbatim, substring of saved source)
- PMID 42311395 — Objective Canine idiopathic epilepsy (IE) is one of the most common neurological diseases in veterinary medicine, with no comprehensive study in China.
- PMID 41737686 — The aim of this study is twofold: to characterize the epidemiology of idiopathic epilepsy (IE) in a large US primary care provider, and to investigate primary care veterinarians' anti-seizure drugs (ASDs) prescribing practices.
- PMID 42280378 — Background: Emerging evidence indicates that epilepsy extends beyond the brain, involving systemic metabolic, immune, and microbiome perturbations that shape neuronal excitability and treatment response.
- PMID 40497364 — In human medicine, focal seizures can clinically express as autonomic signs, such as gastrointestinal dysfunction, cardiovascular changes, and variation of pupillary size; but little is known about possible presentations of autonomic seizures in veterinary medicine.
- PMID 41463899 — Canine epilepsy often resists conventional antiepileptic drugs (AEDs), which affects their quality of life.
- PMID 40509058 — Neurobehavioral comorbidities in dogs with idiopathic epilepsy (IE) are increasingly recognized, yet their phenotypic variability and clinical implications remain poorly understood.
Studies (PMID / year / journal / title)
- PMID 42311395 (2026, Frontiers in veterinary science) — A multicenter retrospective analysis of canine idiopathic epilepsy in China.
- PMID 41737686 (2026, Frontiers in veterinary science) — Retrospective study on canine idiopathic epilepsy treatment in primary care practices in the United States.
- PMID 42280378 (2026, Nutrients) — Canine Idiopathic Epilepsy as a Natural Animal Model for Human Epilepsy: A Scoping Review Highlighting Metabolic Perspectives Beyond the Brain.
- PMID 40497364 (2025, Journal of veterinary internal medicine) — Focal Autonomic Seizures Manifesting With Prevailing Signs of Gastrointestinal Disorder in Dogs.
- PMID 41463899 (2025, Animals : an open access journal from MDPI) — An Exploratory Study of Cannabidiol as an Adjunctive Treatment for Refractory Epilepsy in Dogs.
- PMID 40509058 (2025, Animals : an open access journal from MDPI) — Neurobehavioral Comorbidities in Canine Idiopathic Epilepsy: New Insights into Cognitive and Emotional Domains.
Source text: pdf-raw/evidence/pubmed_evidence_canine_epilepsy_management_2026-07-24.txt (Europe PMC first-hand abstracts, pulled 2026-07-24).