{"topic_id":"evidence_canine_epilepsy_management","category":"evidence","context":"---\ntopic_id: evidence_canine_epilepsy_management\ncategory: evidence\ntitle: \"Evidence cluster — canine epilepsy: antiepileptic drug management (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-24\"\nsource_file: pdf-raw/evidence/pubmed_evidence_canine_epilepsy_management_2026-07-24.txt\ndate_parsed: 2026-07-24\ntokens_estimated: 420\nverified: true\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-07-24\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 42311395\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — canine epilepsy: antiepileptic drug management (peer-reviewed, Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/42311395/\"\n  retrieved: \"2026-07-24\"\n  ref: \"PMID 42311395\"\n  doc_type: \"official PDF\"\n  needs_review: false\nlicense: cc_by\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: canine epilepsy: antiepileptic drug management (peer-reviewed, Europe PMC)\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-24. Query: `(canine epilepsy OR epileptic dog) AND (antiepileptic OR phenobarbital OR imepitoin OR management OR treatment)`. The cluster returns **6** first-hand abstracts extracted below (verbatim sentences, each traceable by PMID).\n\n## Verified claims (verbatim, substring of saved source)\n- **PMID 42311395** — Objective Canine idiopathic epilepsy (IE) is one of the most common neurological diseases in veterinary medicine, with no comprehensive study in China.\n- **PMID 41737686** — The aim of this study is twofold: to characterize the epidemiology of idiopathic epilepsy (IE) in a large US primary care provider, and to investigate primary care veterinarians' anti-seizure drugs (ASDs) prescribing practices.\n- **PMID 42280378** — Background: Emerging evidence indicates that epilepsy extends beyond the brain, involving systemic metabolic, immune, and microbiome perturbations that shape neuronal excitability and treatment response.\n- **PMID 40497364** — In human medicine, focal seizures can clinically express as autonomic signs, such as gastrointestinal dysfunction, cardiovascular changes, and variation of pupillary size; but little is known about possible presentations of autonomic seizures in veterinary medicine.\n- **PMID 41463899** — Canine epilepsy often resists conventional antiepileptic drugs (AEDs), which affects their quality of life.\n- **PMID 40509058** — Neurobehavioral comorbidities in dogs with idiopathic epilepsy (IE) are increasingly recognized, yet their phenotypic variability and clinical implications remain poorly understood.\n\n## Studies (PMID / year / journal / title)\n- **PMID 42311395 (2026, Frontiers in veterinary science)** — A multicenter retrospective analysis of canine idiopathic epilepsy in China.\n- **PMID 41737686 (2026, Frontiers in veterinary science)** — Retrospective study on canine idiopathic epilepsy treatment in primary care practices in the United States.\n- **PMID 42280378 (2026, Nutrients)** — Canine Idiopathic Epilepsy as a Natural Animal Model for Human Epilepsy: A Scoping Review Highlighting Metabolic Perspectives Beyond the Brain.\n- **PMID 40497364 (2025, Journal of veterinary internal medicine)** — Focal Autonomic Seizures Manifesting With Prevailing Signs of Gastrointestinal Disorder in Dogs.\n- **PMID 41463899 (2025, Animals : an open access journal from MDPI)** — An Exploratory Study of Cannabidiol as an Adjunctive Treatment for Refractory Epilepsy in Dogs.\n- **PMID 40509058 (2025, Animals : an open access journal from MDPI)** — Neurobehavioral Comorbidities in Canine Idiopathic Epilepsy: New Insights into Cognitive and Emotional Domains.\n\nSource text: `pdf-raw/evidence/pubmed_evidence_canine_epilepsy_management_2026-07-24.txt` (Europe PMC first-hand abstracts, pulled 2026-07-24).\n\n## License & attribution\n\nSource abstracts / records are Open Access under Creative Commons. Each referenced\nstudy is reproduced with attribution under its specific CC license (CC BY / CC BY-NC /\nCC BY-NC-ND); the exact license variant for each reference is stated on its Europe PMC /\nPMC record. Original records:\n- https://pubmed.ncbi.nlm.nih.gov/40497364/\n- https://pubmed.ncbi.nlm.nih.gov/40509058/\n- https://pubmed.ncbi.nlm.nih.gov/41463899/\n- https://pubmed.ncbi.nlm.nih.gov/41737686/\n- https://pubmed.ncbi.nlm.nih.gov/42280378/\n- https://pubmed.ncbi.nlm.nih.gov/42311395/\n","sources":["Europe PMC — Evidence cluster — canine epilepsy: antiepileptic drug management (peer-reviewed, Europe PMC) (retrieved 2026-07-24)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — canine epilepsy: antiepileptic drug management (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/42311395/","retrieved":"2026-07-24","ref":"PMID 42311395","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 42311395","verification_file":"pdf-raw/evidence/pubmed_evidence_canine_epilepsy_management_2026-07-24.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 42311395","source_file":"pdf-raw/evidence/pubmed_evidence_canine_epilepsy_management_2026-07-24.txt","trust":{"authority_tier":"T2","fidelity":"verbatim","license":"cc_by","display_grade":"A"},"tokens_estimated":726,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}