Overview
The ATCvet QP category covers antiparasitic products, insecticides, and repellents. Within the EMA Union Product Database (medicines-output-medicines-report, dataset generated 20/07/2026), the QP-classified pet medicines for dogs and cats are dominated by ectoparasiticides (flea/tick products) and endectocides (macrocyclic lactones). Most carry Withdrawn or Application withdrawn status.
Ectoparasiticides for Dogs and Cats
Comfortis (spinosad) — EMEA/V/C/002233
- ATCvet code: QP53BX03
- INN: Spinosad (INN: spinosad)
- Active substance: spinosad
- Species: Dogs;Cats
- Status: Withdrawn
- Pharmacotherapeutic group: Other ectoparasiticides for systemic use
- Indication: Treatment and prevention of flea infestations (*Ctenocephalides felis*); preventive effect against re-infestations maintained for 4 weeks
- Marketing authorisation holder: Elanco GmbH
Activyl Tick Plus (indoxacarb;permethrin) — EMEA/V/C/002234
- ATCvet code: QP53AC54
- INN: Indoxacarb;Permethrin (INN: indoxacarb; permethrin)
- Active substance: indoxacarb; permethrin
- Species: Dogs
- Status: Withdrawn
- Pharmacotherapeutic group: Ectoparasiticides for topical use, incl. insecticides
- Indication: Treatment of flea infestations (*Ctenocephalides felis*); persistent insecticidal efficacy for up to 4 weeks against ticks
- Marketing authorisation holder: Intervet International BV
ProMeris (metaflumizone) — EMEA/V/C/000107
- ATCvet code: QP53AX25
- INN: Metaflumizone (INN: metaflumizone)
- Active substance: metaflumizone
- Species: Cats
- Status: Withdrawn
- Pharmacotherapeutic group: Ectoparasiticides for topical use, incl. insecticides
- Indication: Treatment and prevention of flea infestations (*Ctenocephalides canis* and *C. felis*) in cats
- Marketing authorisation holder: Pfizer Limited
ProMeris Duo (metaflumizone;amitraz) — EMEA/V/C/000108
- ATCvet code: QP53AD51
- INN: Metaflumizone;Amitraz (INN: metaflumizone; amitraz)
- Active substance: metaflumizone; amitraz
- Species: Dogs
- Status: Withdrawn
- Pharmacotherapeutic group: Ectoparasiticides for topical use, incl. insecticides
- Indication: Treatment and prevention of flea and tick infestations (*Ctenocephalides* spp., *Ixodes ricinus*, *Dermacentor reticulatus*, *Rhipicephalus sanguineus*) in dogs
- Marketing authorisation holder: Pfizer Limited
Certifect (fipronil/amitraz/(S)-methoprene) — EMEA/V/C/002002
- ATCvet code: QP53AX65
- INN: Fipronil / Amitraz / (S)-Methoprene (INN: fipronil; amitraz; (S)-methoprene)
- Active substance: fipronil; amitraz; (S)-methoprene
- Species: Dogs
- Status: Withdrawn
- Pharmacotherapeutic group: Ectoparasiticides for topical use, incl. insecticides
- Indication: Treatment and prevention of tick (*Ixodes ricinus*, *Dermacentor reticulatus*, *Rhipicephalus sanguineus*) and flea (*Ctenocephalides* spp.) infestations in dogs
- Marketing authorisation holder: Merial
Cheristin — EMEA/V/C/004316
- ATCvet code: QP53AX
- Species: Cats
- Status: Application withdrawn
- Indication: Treatment and prevention of flea infestations (*Ctenocephalides felis*) on cats
- Marketing authorisation holder: Elanco Europe Ltd
Endectocides
Longrange (eprinomectin) — EMEA/V/C/004291
- ATCvet code: QP54AA04
- INN: Eprinomectin (INN: eprinomectin)
- Active substance: eprinomectin
- Species: Cattle
- Status: Refused
- Pharmacotherapeutic group: Endectocides
- Indication: Gastrointestinal roundworms (adult and L4): *Ostertagia ostertagi/lyrata*, *Cooperia* spp., *Haemonchus placei*, *Trichostrongylus* spp., *Nematodirus* spp., *Chabertia ovina*; lungworms: *Dictyocaulus viviparus*; eyeworms: *Thelazia* spp.; mites: *Chorioptes bovis*, *Sarcoptes scabiei* var. *bovis*; lice: *Bovicola bovis*, *Linognathus vituli*, *Haematopinus eurysternus*
- Marketing authorisation holder: Merial
Trifexis (spinosad;milbemycin oxime) — EMEA/V/C/002635
- ATCvet code: QP54AB51
- INN: Spinosad;Milbemycin oxime (INN: spinosad; milbemycin oxime)
- Active substance: spinosad; milbemycin oxime
- Species: Dogs
- Status: Expired
- Pharmacotherapeutic group: Antiparasitic products, insecticides and repellents; Endectocides
- Indication: For the treatment and prevention of flea (*Ctenocephalides felis*) infestations in dogs where one or more of the following parasite species are present or are at risk of mixed infestations with: ticks, gastrointestinal nematodes, or heartworm (dirofilaria immitis)
- Marketing authorisation holder: Eli Lilly and Company Limited
Summary Table
| Product | INN | Species | ATCvet | Status | Target |
|---|---|---|---|---|---|
| Comfortis | spinosad | Dogs;Cats | QP53BX03 | Withdrawn | Fleas (C. felis) |
| Activyl Tick Plus | indoxacarb;permethrin | Dogs | QP53AC54 | Withdrawn | Fleas + ticks |
| ProMeris | metaflumizone | Cats | QP53AX25 | Withdrawn | Fleas |
| ProMeris Duo | metaflumizone;amitraz | Dogs | QP53AD51 | Withdrawn | Fleas + ticks |
| Certifect | fipronil;amitraz;(S)-methoprene | Dogs | QP53AX65 | Withdrawn | Fleas + ticks |
| Cheristin | (not recorded) | Cats | QP53AX | App. withdrawn | Fleas |
| Longrange | eprinomectin | Cattle | QP54AA04 | Refused | GI nematodes, lungworms, mites, lice |
| Trifexis | spinosad;milbemycin oxime | Dogs | QP54AB51 | Expired | Fleas + GI nematodes + heartworm |
Source: EMA medicines-output-medicines-report_en.xlsx, dataset generated 20/07/2026 - 18:00, accessed via https://www.ema.europa.eu/en/medicines/download-medicine-data.