{"topic_id":"eu_ema_qp_antiparasitics_pet","category":"eu-2026-approvals","context":"---\ntopic_id: eu_ema_qp_antiparasitics_pet\ncategory: eu-2026-approvals\ntitle: \"EU EMA Veterinary Antiparasitics: Flea, Tick, and Endectocide Products for Dogs and Cats\"\nlang: en\nsource: \"ema-medicines-report.xlsx\"\ndate_parsed: \"2026-07-21\"\ntokens_estimated: 280\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: \"2026-07-21\"\n---\n\n## Overview\n\nThe ATCvet **QP** category covers antiparasitic products, insecticides, and repellents. Within the EMA Union Product Database (medicines-output-medicines-report, dataset generated 20/07/2026), the QP-classified pet medicines for dogs and cats are dominated by ectoparasiticides (flea/tick products) and endectocides (macrocyclic lactones). Most carry **Withdrawn** or **Application withdrawn** status.\n\n## Ectoparasiticides for Dogs and Cats\n\n### Comfortis (spinosad) — EMEA/V/C/002233\n\n- **ATCvet code**: QP53BX03\n- **INN**: Spinosad (INN: spinosad)\n- **Active substance**: spinosad\n- **Species**: Dogs;Cats\n- **Status**: Withdrawn\n- **Pharmacotherapeutic group**: Other ectoparasiticides for systemic use\n- **Indication**: Treatment and prevention of flea infestations (*Ctenocephalides felis*); preventive effect against re-infestations maintained for 4 weeks\n- **Marketing authorisation holder**: Elanco GmbH\n\n### Activyl Tick Plus (indoxacarb;permethrin) — EMEA/V/C/002234\n\n- **ATCvet code**: QP53AC54\n- **INN**: Indoxacarb;Permethrin (INN: indoxacarb; permethrin)\n- **Active substance**: indoxacarb; permethrin\n- **Species**: Dogs\n- **Status**: Withdrawn\n- **Pharmacotherapeutic group**: Ectoparasiticides for topical use, incl. insecticides\n- **Indication**: Treatment of flea infestations (*Ctenocephalides felis*); persistent insecticidal efficacy for up to 4 weeks against ticks\n- **Marketing authorisation holder**: Intervet International BV\n\n### ProMeris (metaflumizone) — EMEA/V/C/000107\n\n- **ATCvet code**: QP53AX25\n- **INN**: Metaflumizone (INN: metaflumizone)\n- **Active substance**: metaflumizone\n- **Species**: Cats\n- **Status**: Withdrawn\n- **Pharmacotherapeutic group**: Ectoparasiticides for topical use, incl. insecticides\n- **Indication**: Treatment and prevention of flea infestations (*Ctenocephalides canis* and *C. felis*) in cats\n- **Marketing authorisation holder**: Pfizer Limited\n\n### ProMeris Duo (metaflumizone;amitraz) — EMEA/V/C/000108\n\n- **ATCvet code**: QP53AD51\n- **INN**: Metaflumizone;Amitraz (INN: metaflumizone; amitraz)\n- **Active substance**: metaflumizone; amitraz\n- **Species**: Dogs\n- **Status**: Withdrawn\n- **Pharmacotherapeutic group**: Ectoparasiticides for topical use, incl. insecticides\n- **Indication**: Treatment and prevention of flea and tick infestations (*Ctenocephalides* spp., *Ixodes ricinus*, *Dermacentor reticulatus*, *Rhipicephalus sanguineus*) in dogs\n- **Marketing authorisation holder**: Pfizer Limited\n\n### Certifect (fipronil/amitraz/(S)-methoprene) — EMEA/V/C/002002\n\n- **ATCvet code**: QP53AX65\n- **INN**: Fipronil / Amitraz / (S)-Methoprene (INN: fipronil; amitraz; (S)-methoprene)\n- **Active substance**: fipronil; amitraz; (S)-methoprene\n- **Species**: Dogs\n- **Status**: Withdrawn\n- **Pharmacotherapeutic group**: Ectoparasiticides for topical use, incl. insecticides\n- **Indication**: Treatment and prevention of tick (*Ixodes ricinus*, *Dermacentor reticulatus*, *Rhipicephalus sanguineus*) and flea (*Ctenocephalides* spp.) infestations in dogs\n- **Marketing authorisation holder**: Merial\n\n### Cheristin — EMEA/V/C/004316\n\n- **ATCvet code**: QP53AX\n- **Species**: Cats\n- **Status**: Application withdrawn\n- **Indication**: Treatment and prevention of flea infestations (*Ctenocephalides felis*) on cats\n- **Marketing authorisation holder**: Elanco Europe Ltd\n\n## Endectocides\n\n### Longrange (eprinomectin) — EMEA/V/C/004291\n\n- **ATCvet code**: QP54AA04\n- **INN**: Eprinomectin (INN: eprinomectin)\n- **Active substance**: eprinomectin\n- **Species**: Cattle\n- **Status**: Refused\n- **Pharmacotherapeutic group**: Endectocides\n- **Indication**: Gastrointestinal roundworms (adult and L4): *Ostertagia ostertagi/lyrata*, *Cooperia* spp., *Haemonchus placei*, *Trichostrongylus* spp., *Nematodirus* spp., *Chabertia ovina*; lungworms: *Dictyocaulus viviparus*; eyeworms: *Thelazia* spp.; mites: *Chorioptes bovis*, *Sarcoptes scabiei* var. *bovis*; lice: *Bovicola bovis*, *Linognathus vituli*, *Haematopinus eurysternus*\n- **Marketing authorisation holder**: Merial\n\n### Trifexis (spinosad;milbemycin oxime) — EMEA/V/C/002635\n\n- **ATCvet code**: QP54AB51\n- **INN**: Spinosad;Milbemycin oxime (INN: spinosad; milbemycin oxime)\n- **Active substance**: spinosad; milbemycin oxime\n- **Species**: Dogs\n- **Status**: Expired\n- **Pharmacotherapeutic group**: Antiparasitic products, insecticides and repellents; Endectocides\n- **Indication**: For the treatment and prevention of flea (*Ctenocephalides felis*) infestations in dogs where one or more of the following parasite species are present or are at risk of mixed infestations with: ticks, gastrointestinal nematodes, or heartworm (dirofilaria immitis)\n- **Marketing authorisation holder**: Eli Lilly and Company Limited\n\n## Summary Table\n\n| Product | INN | Species | ATCvet | Status | Target |\n|---|---|---|---|---|---|\n| Comfortis | spinosad | Dogs;Cats | QP53BX03 | Withdrawn | Fleas (C. felis) |\n| Activyl Tick Plus | indoxacarb;permethrin | Dogs | QP53AC54 | Withdrawn | Fleas + ticks |\n| ProMeris | metaflumizone | Cats | QP53AX25 | Withdrawn | Fleas |\n| ProMeris Duo | metaflumizone;amitraz | Dogs | QP53AD51 | Withdrawn | Fleas + ticks |\n| Certifect | fipronil;amitraz;(S)-methoprene | Dogs | QP53AX65 | Withdrawn | Fleas + ticks |\n| Cheristin | (not recorded) | Cats | QP53AX | App. withdrawn | Fleas |\n| Longrange | eprinomectin | Cattle | QP54AA04 | Refused | GI nematodes, lungworms, mites, lice |\n| Trifexis | spinosad;milbemycin oxime | Dogs | QP54AB51 | Expired | Fleas + GI nematodes + heartworm |\n\nSource: EMA medicines-output-medicines-report_en.xlsx, dataset generated 20/07/2026 - 18:00, accessed via `https://www.ema.europa.eu/en/medicines/download-medicine-data`.\n","sources":[],"tokens_estimated":280,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}