EU EMA Veterinary Cardiovascular Medicines: Spironolactone and Amlodipine for Dogs and Cats

Overview

The ATCvet QC category covers the cardiovascular system. Within the EMA Union Product Database (medicines-output-medicines-report, dataset generated 20/07/2026), the QC-classified pet medicines are limited to two products: a diuretic for canine congestive heart failure and a calcium channel blocker for feline hypertension. Both target dogs or cats as the indicated species.

QC Cardiovascular Veterinary Medicines in EMA Database

Spironolactone Ceva — EMEA/V/C/000105

• ATCvet code: QC03DA01
• INN: Spironolactone (INN: spironolactone)
• Active substance: spironolactone
• Species: Dogs
• Status: Withdrawn
• Pharmacotherapeutic group: Diuretics
• Therapeutic indication: For use in combination with standard therapy (including diuretic support, where necessary) for the treatment of congestive heart failure in dogs
• Marketing authorisation holder: Ceva Santé Animale
• Note: Spironolactone is a potassium-sparing aldosterone antagonist diuretic. QC03DA01 places it in the "diuretics" (C03) subclass under cardiovascular (C).

Lodipressin — EMEA/V/C/003786

• ATCvet code: QC08CA01
• INN: Amlodipine (INN: amlodipine)
• Active substance: amlodipine besilate
• Species: Cats
• Status: Refused
• Pharmacotherapeutic group: Calcium channel blockers
• Therapeutic indication: Treatment of systemic arterial hypertension in cats
• Marketing authorisation holder: Le Vet Beheer B.V.
• Note: Amlodipine is a long-acting dihydropyridine calcium channel blocker (C08CA01 = amlodipine). In human medicine it is a first-line antihypertensive; in veterinary medicine it is used off-label and as a formulated product for feline systemic hypertension.

Key Facts

1. QC03DA01 = spironolactone for dogs — indicated for canine congestive heart failure as adjunct therapy (EMEA/V/C/000105, Withdrawn status, Ceva Santé Animale holder).
2. QC08CA01 = amlodipine for cats — indicated for feline systemic arterial hypertension (EMEA/V/C/003786, Refused status, Le Vet Beheer B.V. applicant).
3. Both products have a non-Authorised status (one Withdrawn, one Refused), meaning neither is currently marketed in the EU under this MA number.
4. The feline hypertension indication (systemic arterial hypertension in cats) is a recognised clinical need; amlodipine besilate is the active substance.
5. The EMA product numbers follow the pattern EMEA/V/C/XXXXXX for veterinary centrally authorised products.

Source: EMA medicines-output-medicines-report_en.xlsx, dataset generated 20/07/2026 - 18:00, accessed via https://www.ema.europa.eu/en/medicines/download-medicine-data.