{"topic_id":"eu_ema_qc_cardiovascular_pet","category":"eu-2026-approvals","context":"---\ntopic_id: eu_ema_qc_cardiovascular_pet\ncategory: eu-2026-approvals\ntitle: \"EU EMA Veterinary Cardiovascular Medicines: Spironolactone and Amlodipine for Dogs and Cats\"\nlang: en\nsource: \"ema-medicines-report.xlsx\"\ndate_parsed: \"2026-07-21\"\ntokens_estimated: 280\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: \"2026-07-21\"\n---\n\n## Overview\n\nThe ATCvet **QC** category covers the cardiovascular system. Within the EMA Union Product Database (medicines-output-medicines-report, dataset generated 20/07/2026), the QC-classified pet medicines are limited to two products: a diuretic for canine congestive heart failure and a calcium channel blocker for feline hypertension. Both target dogs or cats as the indicated species.\n\n## QC Cardiovascular Veterinary Medicines in EMA Database\n\n### Spironolactone Ceva — EMEA/V/C/000105\n\n- **ATCvet code**: QC03DA01\n- **INN**: Spironolactone (INN: spironolactone)\n- **Active substance**: spironolactone\n- **Species**: Dogs\n- **Status**: Withdrawn\n- **Pharmacotherapeutic group**: Diuretics\n- **Therapeutic indication**: For use in combination with standard therapy (including diuretic support, where necessary) for the treatment of congestive heart failure in dogs\n- **Marketing authorisation holder**: Ceva Santé Animale\n- **Note**: Spironolactone is a potassium-sparing aldosterone antagonist diuretic. QC03DA01 places it in the \"diuretics\" (C03) subclass under cardiovascular (C).\n\n### Lodipressin — EMEA/V/C/003786\n\n- **ATCvet code**: QC08CA01\n- **INN**: Amlodipine (INN: amlodipine)\n- **Active substance**: amlodipine besilate\n- **Species**: Cats\n- **Status**: Refused\n- **Pharmacotherapeutic group**: Calcium channel blockers\n- **Therapeutic indication**: Treatment of systemic arterial hypertension in cats\n- **Marketing authorisation holder**: Le Vet Beheer B.V.\n- **Note**: Amlodipine is a long-acting dihydropyridine calcium channel blocker (C08CA01 = amlodipine). In human medicine it is a first-line antihypertensive; in veterinary medicine it is used off-label and as a formulated product for feline systemic hypertension.\n\n## Key Facts\n\n1. **QC03DA01 = spironolactone for dogs** — indicated for canine congestive heart failure as adjunct therapy (EMEA/V/C/000105, Withdrawn status, Ceva Santé Animale holder).\n2. **QC08CA01 = amlodipine for cats** — indicated for feline systemic arterial hypertension (EMEA/V/C/003786, Refused status, Le Vet Beheer B.V. applicant).\n3. Both products have a non-Authorised status (one Withdrawn, one Refused), meaning neither is currently marketed in the EU under this MA number.\n4. The feline hypertension indication (systemic arterial hypertension in cats) is a recognised clinical need; amlodipine besilate is the active substance.\n5. The EMA product numbers follow the pattern `EMEA/V/C/XXXXXX` for veterinary centrally authorised products.\n\nSource: EMA medicines-output-medicines-report_en.xlsx, dataset generated 20/07/2026 - 18:00, accessed via `https://www.ema.europa.eu/en/medicines/download-medicine-data`.\n","sources":[],"tokens_estimated":280,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}