--- license: permission_granted topic_id: companion_species_health_wilson_disease_cat category: companion-species-health title: "Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/cat_wilson_disease_4249.txt date_parsed: 2026-08-24 tokens_estimated: 209 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_wilson_disease_cat/01_companion_species_health_wilson_disease_cat.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001071/9685/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: Wilson diseaseClin feat: Asada et al. (2019): "A 9‐month‐old intact crossbred female cat was presented with jaundice, intermittent anorexia and lethargy, increased hepatic enzyme activities, and hyperammonemia. Abdominal ultrasound and computed tomographic examinations determined that the liver had a rounded and irregular margin, and histopathological examination identified excessive accumulation of copper hepatocytes in the liver. Concentrations of both blood and urine copper were higher than in healthy cats."Prevalence: In a survey of 54 cats for whom "intraoperative liver tissue specimens" were available, Asada et al. (2020) reported 4 with "hepatic copper accumulation (HCA)", three of which had "single-nucleotide variations in ATP7B ".
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389721739 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Noting the similarity of the clinical signs of a single "crossbred" cat (described in Clinical features section) to Wilson disease in humans, Asada et al. (2019) sequenced comparative functional genes in the affected cat and identified the variant c.3890C>G (p. T1297R, omia.variant:1136) of the <em>ATP7B</em> gene as being likely causal. The authors reported that "the patient and its litte…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2019. Hepatic copper accumulation in a young cat with familial variations in the ATP7B gene. J Vet Intern Med — PubMed:PMID30561139 | DOI:10.1111/jvim.15399 — OMIA Phene_Article / Article
- 2020. Variations in ATP7B in cats with primary copper-associated hepatopathy. J Feline Med Surg — PubMed:PMID31687873 | DOI:10.1177/1098612X19884763 — OMIA Phene_Article / Article
- 2023. Diagnosis, management and genetic analysis of a cat with primary copper hepatopathy. JFMS Open Rep — PubMed:PMID37427085 | DOI:10.1177/20551169231177275 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:277900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:606882 (type: gene) — OMIA Group_OMIM (via OMIA_ID)