{"topic_id":"companion_species_health_wilson_disease_cat","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_wilson_disease_cat\ncategory: companion-species-health\ntitle: \"Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/cat_wilson_disease_4249.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 209\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_wilson_disease_cat/01_companion_species_health_wilson_disease_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001071/9685/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Cat (Felis catus)`\n- `Disorder: Wilson disease`\n- `Clin feat: Asada et al. (2019): \"A 9‐month‐old intact crossbred female cat was presented with jaundice, intermittent anorexia and lethargy, increased hepatic enzyme activities, and hyperammonemia. Abdominal ultrasound and computed tomographic examinations determined that the liver had a rounded and irregular margin, and histopathological examination identified excessive accumulation of copper hepatocytes in the liver. Concentrations of both blood and urine copper were higher than in healthy cats.\"`\n- `Prevalence: In a survey of 54 cats for whom \"intraoperative liver tissue specimens\" were available, Asada et al. (2020) reported 4 with \"hepatic copper accumulation (HCA)\", three of which had \"single-nucleotide variations in ATP7B \".`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 389721739 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Noting the similarity of the clinical signs of a single \"crossbred\" cat (described in Clinical features section) to Wilson disease in humans, Asada et al. (2019) sequenced comparative functional genes in the affected cat and identified the variant c.3890C&gt;G (p. T1297R, omia.variant:1136) of the&nbsp;<em>ATP7B</em> gene as being likely causal. The authors reported that \"the patient and its litte…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2019. Hepatic copper accumulation in a young cat with familial variations in the ATP7B gene. J Vet Intern Med — PubMed:PMID30561139 | DOI:10.1111/jvim.15399 — OMIA Phene_Article / Article\n- 2020. Variations in ATP7B in cats with primary copper-associated hepatopathy. J Feline Med Surg — PubMed:PMID31687873 | DOI:10.1177/1098612X19884763 — OMIA Phene_Article / Article\n- 2023. Diagnosis, management and genetic analysis of a cat with primary copper hepatopathy. JFMS Open Rep — PubMed:PMID37427085 | DOI:10.1177/20551169231177275 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:277900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606882 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Cat (Felis catus) — Wilson disease (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/30561139/","retrieved":"","ref":"PMID 30561139","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":733,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}