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Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)

companion_species_health_thrombopathia_dog

companion-species-health en

--- license: permission_granted topic_id: companion_species_health_thrombopathia_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_thrombopathia_1731.txt date_parsed: 2026-08-24 tokens_estimated: 164 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_thrombopathia_dog/01_companion_species_health_thrombopathia_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001003/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose." verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Dog (Canis lupus familiaris)
  • Disorder: Thrombopathia
  • Summary: Boudreaux et al. (2007) reported likely causal variants in Calcium-Diacylglycerol Guanine Nucleotide Exchange Factor I (CalDAG-GEFI) for Landseer, Eskimo Spitz and Basset Hound breeds. Based on NCBI information the gene name was initially listed as RASGRP1 gene in OMIA. A recent BLAST search of the published data identified that the correct gene name is RASGRP2 and information relating to the RASGRP2 variants in these breeds have been moved to: OMIA 002433-9615 : Thrombopathia, RASGRP2-related in Canis lupus familiaris [22/01/2022]

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1989. Absent platelet aggregation with normal fibrinogen binding in Basset Hound hereditary thrombopathy. Thromb Haemost — PubMed:PMID2512673 — OMIA Phene_Article / Article
  • 1993. Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thromb Haemost — PubMed:PMID8128434 — OMIA Phene_Article / Article
  • 1994. Identification of an intrinsic platelet function defect in Spitz dogs. J Vet Intern Med — PubMed:PMID8046682 | DOI:10.1111/j.1939-1676.1994.tb03204.x — OMIA Phene_Article / Article
  • 1995. Inherited platelet delta-storage pool disease in dogs causing severe bleeding - an animal model for a specific adp deficiency. Thrombosis & Haemostasis — OMIA Phene_Article / Article
  • 2007. Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. Transl Res — PubMed:PMID17656327 | DOI:10.1016/j.trsl.2007.03.006 — OMIA Phene_Article / Article
  • 2008. Characteristics, diagnosis, and treatment of inherited platelet disorders in mammals. J Am Vet Med Assoc — PubMed:PMID18922051 | DOI:10.2460/javma.233.8.1251 — OMIA Phene_Article / Article
  • 1979. An inherited platelet function defect in Basset hounds. Can Vet J — PubMed:PMID509382 — OMIA Phene_Article / Article
  • 1986. Defective platelet-fibrinogen interaction in hereditary canine thrombopathia. Blood — PubMed:PMID3011147 — OMIA Phene_Article / Article
  • 1988. Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract — PubMed:PMID3258696 — OMIA Phene_Article / Article
  • 2012. Inherited platelet disorders. J Vet Emerg Crit Care (San Antonio) — PubMed:PMID22316339 | DOI:10.1111/j.1476-4431.2011.00702.x — OMIA Phene_Article / Article
  • 1985. Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy. Thromb Res — PubMed:PMID3983903 | DOI:10.1016/0049-3848(85)90033-7 — OMIA Phene_Article / Article
  • 2018. Assembly and analysis of unmapped genome sequence reads reveal novel sequence and variation in dogs. Sci Rep — PubMed:PMID30022108 | DOI:10.1038/s41598-018-29190-3 — OMIA Phene_Article / Article
  • (1 additional references in OMIA)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1989. Absent platelet aggregation with normal fibrinogen binding in Basset Hound hereditary thrombopathy. Thromb Haemost — PubMed:PMID2512673 — OMIA Phene_Article / Article
  • 1993. Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thromb Haemost — PubMed:PMID8128434 — OMIA Phene_Article / Article
  • 1994. Identification of an intrinsic platelet function defect in Spitz dogs. J Vet Intern Med — PubMed:PMID8046682 | DOI:10.1111/j.1939-1676.1994.tb03204.x — OMIA Phene_Article / Article
  • 1995. Inherited platelet delta-storage pool disease in dogs causing severe bleeding - an animal model for a specific adp deficiency. Thrombosis & Haemostasis — OMIA Phene_Article / Article
  • 2007. Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. Transl Res — PubMed:PMID17656327 | DOI:10.1016/j.trsl.2007.03.006 — OMIA Phene_Article / Article
  • 2008. Characteristics, diagnosis, and treatment of inherited platelet disorders in mammals. J Am Vet Med Assoc — PubMed:PMID18922051 | DOI:10.2460/javma.233.8.1251 — OMIA Phene_Article / Article
  • 1979. An inherited platelet function defect in Basset hounds. Can Vet J — PubMed:PMID509382 — OMIA Phene_Article / Article
  • 1986. Defective platelet-fibrinogen interaction in hereditary canine thrombopathia. Blood — PubMed:PMID3011147 — OMIA Phene_Article / Article
  • 1988. Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract — PubMed:PMID3258696 — OMIA Phene_Article / Article
  • 2012. Inherited platelet disorders. J Vet Emerg Crit Care (San Antonio) — PubMed:PMID22316339 | DOI:10.1111/j.1476-4431.2011.00702.x — OMIA Phene_Article / Article
  • 1985. Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy. Thromb Res — PubMed:PMID3983903 | DOI:10.1016/0049-3848(85)90033-7 — OMIA Phene_Article / Article
  • 2018. Assembly and analysis of unmapped genome sequence reads reveal novel sequence and variation in dogs. Sci Rep — PubMed:PMID30022108 | DOI:10.1038/s41598-018-29190-3 — OMIA Phene_Article / Article
  • (1 additional references in OMIA)

Sources

Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)
companion-species-healthPMID 2512673

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