{"topic_id":"companion_species_health_thrombopathia_dog","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_thrombopathia_dog\ncategory: companion-species-health\ntitle: \"Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/dog_thrombopathia_1731.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 164\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_thrombopathia_dog/01_companion_species_health_thrombopathia_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001003/9615/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Dog (Canis lupus familiaris)`\n- `Disorder: Thrombopathia`\n- `Summary: Boudreaux et al. (2007) reported likely causal variants in Calcium-Diacylglycerol Guanine Nucleotide Exchange Factor I (CalDAG-GEFI) for Landseer, Eskimo Spitz and Basset Hound breeds. Based on NCBI information the gene name was initially listed as RASGRP1 gene in OMIA. A recent BLAST search of the published data identified that the correct gene name is RASGRP2 and information relating to the RASGRP2 variants in these breeds have been moved to: OMIA 002433-9615 : Thrombopathia, RASGRP2-related in Canis lupus familiaris [22/01/2022]`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1989. Absent platelet aggregation with normal fibrinogen binding in  Basset Hound hereditary thrombopathy. Thromb Haemost — PubMed:PMID2512673 — OMIA Phene_Article / Article\n- 1993. Buccal mucosa bleeding time is prolonged in canine models of  primary hemostatic disorders. Thromb Haemost — PubMed:PMID8128434 — OMIA Phene_Article / Article\n- 1994. Identification of an intrinsic platelet function defect in Spitz dogs. J Vet Intern Med — PubMed:PMID8046682 | DOI:10.1111/j.1939-1676.1994.tb03204.x — OMIA Phene_Article / Article\n- 1995. Inherited platelet delta-storage pool disease in dogs causing severe bleeding - an animal model for a specific adp deficiency. Thrombosis & Haemostasis — OMIA Phene_Article / Article\n- 2007. Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. Transl Res — PubMed:PMID17656327 | DOI:10.1016/j.trsl.2007.03.006 — OMIA Phene_Article / Article\n- 2008. Characteristics, diagnosis, and treatment of inherited platelet disorders in mammals. J Am Vet Med Assoc — PubMed:PMID18922051 | DOI:10.2460/javma.233.8.1251 — OMIA Phene_Article / Article\n- 1979. An inherited platelet function defect in Basset hounds. Can Vet J — PubMed:PMID509382 — OMIA Phene_Article / Article\n- 1986. Defective platelet-fibrinogen interaction in hereditary canine thrombopathia. Blood — PubMed:PMID3011147 — OMIA Phene_Article / Article\n- 1988. Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract — PubMed:PMID3258696 — OMIA Phene_Article / Article\n- 2012. Inherited platelet disorders. J Vet Emerg Crit Care (San Antonio) — PubMed:PMID22316339 | DOI:10.1111/j.1476-4431.2011.00702.x — OMIA Phene_Article / Article\n- 1985. Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy. Thromb Res — PubMed:PMID3983903 | DOI:10.1016/0049-3848(85)90033-7 — OMIA Phene_Article / Article\n- 2018. Assembly and analysis of unmapped genome sequence reads reveal novel sequence and variation in dogs. Sci Rep — PubMed:PMID30022108 | DOI:10.1038/s41598-018-29190-3 — OMIA Phene_Article / Article\n- (1 additional references in OMIA)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1989. Absent platelet aggregation with normal fibrinogen binding in  Basset Hound hereditary thrombopathy. Thromb Haemost — PubMed:PMID2512673 — OMIA Phene_Article / Article\n- 1993. Buccal mucosa bleeding time is prolonged in canine models of  primary hemostatic disorders. Thromb Haemost — PubMed:PMID8128434 — OMIA Phene_Article / Article\n- 1994. Identification of an intrinsic platelet function defect in Spitz dogs. J Vet Intern Med — PubMed:PMID8046682 | DOI:10.1111/j.1939-1676.1994.tb03204.x — OMIA Phene_Article / Article\n- 1995. Inherited platelet delta-storage pool disease in dogs causing severe bleeding - an animal model for a specific adp deficiency. Thrombosis & Haemostasis — OMIA Phene_Article / Article\n- 2007. Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. Transl Res — PubMed:PMID17656327 | DOI:10.1016/j.trsl.2007.03.006 — OMIA Phene_Article / Article\n- 2008. Characteristics, diagnosis, and treatment of inherited platelet disorders in mammals. J Am Vet Med Assoc — PubMed:PMID18922051 | DOI:10.2460/javma.233.8.1251 — OMIA Phene_Article / Article\n- 1979. An inherited platelet function defect in Basset hounds. Can Vet J — PubMed:PMID509382 — OMIA Phene_Article / Article\n- 1986. Defective platelet-fibrinogen interaction in hereditary canine thrombopathia. Blood — PubMed:PMID3011147 — OMIA Phene_Article / Article\n- 1988. Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract — PubMed:PMID3258696 — OMIA Phene_Article / Article\n- 2012. Inherited platelet disorders. J Vet Emerg Crit Care (San Antonio) — PubMed:PMID22316339 | DOI:10.1111/j.1476-4431.2011.00702.x — OMIA Phene_Article / Article\n- 1985. Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy. Thromb Res — PubMed:PMID3983903 | DOI:10.1016/0049-3848(85)90033-7 — OMIA Phene_Article / Article\n- 2018. Assembly and analysis of unmapped genome sequence reads reveal novel sequence and variation in dogs. Sci Rep — PubMed:PMID30022108 | DOI:10.1038/s41598-018-29190-3 — OMIA Phene_Article / Article\n- (1 additional references in OMIA)\n","sources":["companion-species-health — Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Dog (Canis lupus familiaris) — Thrombopathia (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/2512673/","retrieved":"","ref":"PMID 2512673","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1257,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}