Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)

--- license: permission_granted topic_id: companion_species_health_shank3_associated_autism_spectrum_disorder_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_shank3_associated_autism_spectrum_disorder_5532.txt date_parsed: 2026-08-24 tokens_estimated: 80 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_shank3_associated_autism_spectrum_disorder_dog/01_companion_species_health_shank3_associated_autism_spectrum_disorder_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA002402/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Species: Dog (Canis lupus familiaris)
• Disorder: SHANK3-associated autism spectrum disorder
• Summary: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 388243383 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2023. Shank3 mutations enhance early neural responses to deviant tones in dogs. Cereb Cortex — PubMed:PMID37585733 | DOI:10.1093/cercor/bhad302 — OMIA Phene_Article / Article
• 2023. Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs. Mol Psychiatry — PubMed:PMID37848709 | DOI:10.1038/s41380-023-02277-8 — OMIA Phene_Article / Article
• 2023. Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing. Mol Psychiatry — PubMed:PMID37848710 | DOI:10.1038/s41380-023-02276-9 — OMIA Phene_Article / Article
• 2024. Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs. Mol Autism — PubMed:PMID38297387 | DOI:10.1186/s13229-024-00587-4 — OMIA Phene_Article / Article
• 2024. Disrupted human-dog interbrain neural coupling in autism-associated SHANK3 mutant dogs. Adv Sci (Weinh) — PubMed:PMID39257367 | DOI:10.1002/advs.202402493 — OMIA Phene_Article / Article
• 2024. Impaired tactile processing in autism-associated Shank3 mutant dogs: neural mechanism and intervention. Sci Bull (Beijing) — PubMed:PMID39294081 | DOI:10.1016/j.scib.2024.09.011 — OMIA Phene_Article / Article
• 2025. Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs. Mol Psychiatry — PubMed:PMID40097608 | DOI:10.1038/s41380-025-02952-y — OMIA Phene_Article / Article
• 2025. Autism-like atypical face processing in Shank3 mutant dogs. Sci Adv — PubMed:PMID40173245 | DOI:10.1126/sciadv.adu3793 — OMIA Phene_Article / Article
• 2025. Reduced attention to human eyes in autism-associated Shank3 mutant laboratory beagle dogs. Mol Psychiatry — PubMed:PMID40148549 | DOI:10.1038/s41380-025-02965-7 — OMIA Phene_Article / Article
• 2025. Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs. Transl Psychiatry — PubMed:PMID40050270 | DOI:10.1038/s41398-025-03296-5 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:606232 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:606230 (type: gene) — OMIA Group_OMIM (via OMIA_ID)