{"topic_id":"companion_species_health_shank3_associated_autism_spectrum_disorder_dog","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_shank3_associated_autism_spectrum_disorder_dog\ncategory: companion-species-health\ntitle: \"Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/dog_shank3_associated_autism_spectrum_disorder_5532.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_shank3_associated_autism_spectrum_disorder_dog/01_companion_species_health_shank3_associated_autism_spectrum_disorder_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA002402/9615/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Dog (Canis lupus familiaris)`\n- `Disorder: SHANK3-associated autism spectrum disorder`\n- `Summary: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 388243383 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2023. Shank3 mutations enhance early neural responses to deviant tones in dogs. Cereb Cortex — PubMed:PMID37585733 | DOI:10.1093/cercor/bhad302 — OMIA Phene_Article / Article\n- 2023. Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs. Mol Psychiatry — PubMed:PMID37848709 | DOI:10.1038/s41380-023-02277-8 — OMIA Phene_Article / Article\n- 2023. Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing. Mol Psychiatry — PubMed:PMID37848710 | DOI:10.1038/s41380-023-02276-9 — OMIA Phene_Article / Article\n- 2024. Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs. Mol Autism — PubMed:PMID38297387 | DOI:10.1186/s13229-024-00587-4 — OMIA Phene_Article / Article\n- 2024. Disrupted human-dog interbrain neural coupling in autism-associated SHANK3 mutant dogs. Adv Sci (Weinh) — PubMed:PMID39257367 | DOI:10.1002/advs.202402493 — OMIA Phene_Article / Article\n- 2024. Impaired tactile processing in autism-associated Shank3 mutant dogs: neural mechanism and intervention. Sci Bull (Beijing) — PubMed:PMID39294081 | DOI:10.1016/j.scib.2024.09.011 — OMIA Phene_Article / Article\n- 2025. Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs. Mol Psychiatry — PubMed:PMID40097608 | DOI:10.1038/s41380-025-02952-y — OMIA Phene_Article / Article\n- 2025. Autism-like atypical face processing in Shank3 mutant dogs. Sci Adv — PubMed:PMID40173245 | DOI:10.1126/sciadv.adu3793 — OMIA Phene_Article / Article\n- 2025. Reduced attention to human eyes in autism-associated Shank3 mutant laboratory beagle dogs. Mol Psychiatry — PubMed:PMID40148549 | DOI:10.1038/s41380-025-02965-7 — OMIA Phene_Article / Article\n- 2025. Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs. Transl Psychiatry — PubMed:PMID40050270 | DOI:10.1038/s41398-025-03296-5 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:606232 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606230 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Dog (Canis lupus familiaris) — SHANK3-associated autism spectrum disorder (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/37585733/","retrieved":"","ref":"PMID 37585733","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":774,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}