--- license: permission_granted topic_id: companion_species_health_pulmonary_fibrosis_idiopathic_cat category: companion-species-health title: "Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/cat_pulmonary_fibrosis_idiopathic_2789.txt date_parsed: 2026-08-24 tokens_estimated: 235 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_pulmonary_fibrosis_idiopathic_cat/01_companion_species_health_pulmonary_fibrosis_idiopathic_cat.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001417/9685/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: Pulmonary fibrosis, idiopathicSummary: The paper by Williams et al. (2004) is the first report of an animal model of human idiopathic pulmonary fibrosis.Pathology: As reported by Williams et al. (2004), the histopathology comprises "(1) interstitial fibrosis with fibroblast/myofibroblast foci, (2) honeycombing with alveolar epithelial metaplasia and type II pneumocyte hyperplasia, and (3) alveolar interstitial smooth-muscle metaplasia. Interstitial inflammation was not a prominent feature of the disease. alpha-Smooth muscle actin-positive myofibroblasts were prominent in myofibroblast foci, beneath honeycomb and hyperplastic epithelium, and in alveolar septa away from the remodeling. Feline IPF type II pneumocyte ultrastructure is similar to a heritable form of human IPF, with abnormal cytoplasmic lamellar body-like inclusions. "
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA entry symbol: IPF (no structured Phene_Gene link)
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2004. Identification of spontaneous feline idiopathic pulmonary fibrosis: morphology and ultrastructural evidence for a type II pneumocyte defect. Chest — PubMed:PMID15189952 | DOI:10.1378/chest.125.6.2278 — OMIA Phene_Article / Article
- 2008. Imaging diagnosis--Feline idiopathic pulmonary fibrosis. Vet Radiol Ultrasound — PubMed:PMID18251294 | DOI:10.1111/j.1740-8261.2007.00316.x — OMIA Phene_Article / Article
- 2004. Identification and characterization of an idiopathic pulmonary fibrosis-like condition in cats. J Vet Intern Med — PubMed:PMID15515577 | DOI:10.1892/0891-6640(2004)18<632:iacoai>2.0.co;2 — OMIA Phene_Article / Article
- 2013. Radiographic and histopathologic characteristics of pulmonary fibrosis in nine cats. Vet Radiol Ultrasound — PubMed:PMID24103063 | DOI:10.1111/vru.12106 — OMIA Phene_Article / Article
- 2026. A multidisciplinary diagnostic approach to pulmonary fibrosis in dogs and cats. J Vet Diagn Invest — PubMed:PMID41653000 | DOI:10.1177/10406387251415196 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:178500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)