{"topic_id":"companion_species_health_pulmonary_fibrosis_idiopathic_cat","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_pulmonary_fibrosis_idiopathic_cat\ncategory: companion-species-health\ntitle: \"Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/cat_pulmonary_fibrosis_idiopathic_2789.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 235\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_pulmonary_fibrosis_idiopathic_cat/01_companion_species_health_pulmonary_fibrosis_idiopathic_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001417/9685/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Cat (Felis catus)`\n- `Disorder: Pulmonary fibrosis, idiopathic`\n- `Summary: The paper by Williams et al. (2004) is the first report of an animal model of human idiopathic pulmonary fibrosis.`\n- `Pathology: As reported by Williams et al. (2004), the histopathology comprises \"(1) interstitial fibrosis with fibroblast/myofibroblast foci, (2) honeycombing with alveolar epithelial metaplasia and type II pneumocyte hyperplasia, and (3) alveolar interstitial smooth-muscle metaplasia. Interstitial inflammation was not a prominent feature of the disease. alpha-Smooth muscle actin-positive myofibroblasts were prominent in myofibroblast foci, beneath honeycomb and hyperplastic epithelium, and in alveolar septa away from the remodeling. Feline IPF type II pneumocyte ultrastructure is similar to a heritable form of human IPF, with abnormal cytoplasmic lamellar body-like inclusions. \"`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIA entry symbol: IPF (no structured Phene_Gene link)\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2004. Identification of spontaneous feline idiopathic pulmonary fibrosis: morphology and ultrastructural evidence for a type II pneumocyte defect. Chest — PubMed:PMID15189952 | DOI:10.1378/chest.125.6.2278 — OMIA Phene_Article / Article\n- 2008. Imaging diagnosis--Feline idiopathic pulmonary fibrosis. Vet Radiol Ultrasound — PubMed:PMID18251294 | DOI:10.1111/j.1740-8261.2007.00316.x — OMIA Phene_Article / Article\n- 2004. Identification and characterization of an idiopathic pulmonary fibrosis-like condition in cats. J Vet Intern Med — PubMed:PMID15515577 | DOI:10.1892/0891-6640(2004)18<632:iacoai>2.0.co;2 — OMIA Phene_Article / Article\n- 2013. Radiographic and histopathologic characteristics of pulmonary fibrosis in nine cats. Vet Radiol Ultrasound — PubMed:PMID24103063 | DOI:10.1111/vru.12106 — OMIA Phene_Article / Article\n- 2026. A multidisciplinary diagnostic approach to pulmonary fibrosis in dogs and cats. J Vet Diagn Invest — PubMed:PMID41653000 | DOI:10.1177/10406387251415196 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:178500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Cat (Felis catus) — Pulmonary fibrosis, idiopathic (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/15189952/","retrieved":"","ref":"PMID 15189952","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":707,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}