Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)

--- license: permission_granted topic_id: companion_species_health_premature_aging_syndrome_rabbit category: companion-species-health title: "Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/rabbit_premature_aging_syndrome_2091.txt date_parsed: 2026-08-24 tokens_estimated: 90 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_premature_aging_syndrome_rabbit/01_companion_species_health_premature_aging_syndrome_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001213/9986/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Species: Rabbit (Oryctolagus cuniculus)
• Disorder: Premature aging syndrome
• Summary: The affected rabbits produced by Sui et al. (2019) are the result of "precise LMNA targeting in rabbits via co-injection of Cas9/sgRNA mRNA into zygotes", i.e. it is a knock-out model of human premature aging inherited disorders.

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 389109936 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1960. Hereditary premature sensescence of the rabbit. I. Chronic form; general features. J Exp Med — PubMed:PMID13733754 | DOI:10.1084/jem.111.4.485 — OMIA Phene_Article / Article
• 1960. Hereditary premature senescence of the rabbit. II. Acute form; general features. J Exp Med — PubMed:PMID13733753 | DOI:10.1084/jem.111.4.505 — OMIA Phene_Article / Article
• 2019. LMNA-mutated rabbits: A model of premature aging syndrome with muscular dystrophy and dilated cardiomyopathy. Aging Dis — PubMed:PMID30705772 | DOI:10.14336/AD.2018.0209 — OMIA Phene_Article / Article
• 2018. Highly efficient RNA-guided base editing in rabbit. Nat Commun — PubMed:PMID30006570 | DOI:10.1038/s41467-018-05232-2 — OMIA Phene_Article / Article
• 2020. Efficient base editing with high precision in rabbits using YFE-BE4max. Cell Death Dis — PubMed:PMID31959743 | DOI:10.1038/s41419-020-2244-3 — OMIA Phene_Article / Article
• 2022. Highly efficient A-to-G base editing by ABE8.17 in rabbits. Mol Ther Nucleic Acids — PubMed:PMID35282412 | DOI:10.1016/j.omtn.2022.01.019 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:150330 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:176670 (type: trait) — OMIA Group_OMIM (via OMIA_ID)