{"topic_id":"companion_species_health_premature_aging_syndrome_rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_premature_aging_syndrome_rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_premature_aging_syndrome_2091.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 90\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_premature_aging_syndrome_rabbit/01_companion_species_health_premature_aging_syndrome_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001213/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: Premature aging syndrome`\n- `Summary: The affected rabbits produced by Sui et al. (2019) are the result of \"precise LMNA targeting in rabbits via co-injection of Cas9/sgRNA mRNA into zygotes\", i.e. it is a knock-out model of human premature aging inherited disorders.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 389109936 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1960. Hereditary premature sensescence of the rabbit. I. Chronic form; general features. J Exp Med — PubMed:PMID13733754 | DOI:10.1084/jem.111.4.485 — OMIA Phene_Article / Article\n- 1960. Hereditary premature senescence of the rabbit. II. Acute form; general features. J Exp Med — PubMed:PMID13733753 | DOI:10.1084/jem.111.4.505 — OMIA Phene_Article / Article\n- 2019. LMNA-mutated rabbits: A model of premature aging syndrome with muscular dystrophy and dilated cardiomyopathy. Aging Dis — PubMed:PMID30705772 | DOI:10.14336/AD.2018.0209 — OMIA Phene_Article / Article\n- 2018. Highly efficient RNA-guided base editing in rabbit. Nat Commun — PubMed:PMID30006570 | DOI:10.1038/s41467-018-05232-2 — OMIA Phene_Article / Article\n- 2020. Efficient base editing with high precision in rabbits using YFE-BE4max. Cell Death Dis — PubMed:PMID31959743 | DOI:10.1038/s41419-020-2244-3 — OMIA Phene_Article / Article\n- 2022. Highly efficient A-to-G base editing by ABE8.17 in rabbits. Mol Ther Nucleic Acids — PubMed:PMID35282412 | DOI:10.1016/j.omtn.2022.01.019 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:150330 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:176670 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — Premature aging syndrome (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/13733754/","retrieved":"","ref":"PMID 13733754","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":659,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}