--- license: permission_granted topic_id: companion_species_health_omia_4226_hamster category: companion-species-health title: "Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/hamster_omia_4226_4226.txt date_parsed: 2026-08-24 tokens_estimated: 80 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_omia_4226_hamster/01_companion_species_health_omia_4226_hamster.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA000499/10036/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Mesocricetus auratus / Phodopus spp. (hamster)Disorder:Summary: Guo et al. (2018) "generated Ldlr-ablated hamsters using CRISPR/Cas9 technology". Thus these animals are genetically-modified organisms (GMO).Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 392710827 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2019. Dietary cholesterol is highly associated with severity of hyperlipidemia and atherosclerotic lesions in heterozygous LDLR-deficient hamsters. Int J Mol Sci — PubMed:PMID31323736 | DOI:10.3390/ijms20143515 — OMIA Phene_Article / Article
- 2018. LDL receptor gene-ablated hamsters: A rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis. EBioMedicine — PubMed:PMID29289533 | DOI:10.1016/j.ebiom.2017.12.013 — OMIA Phene_Article / Article
- 2021. Dietary-induced elevations of triglyceride-rich lipoproteins promote atherosclerosis in the low-density lipoprotein receptor knockout Syrian golden hamster. Front Cardiovasc Med — PubMed:PMID34796210 | DOI:10.3389/fcvm.2021.738060 — OMIA Phene_Article / Article
- 2023. LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway. Toxicol Lett — PubMed:PMID37459939 | DOI:10.1016/j.toxlet.2023.07.009 — OMIA Phene_Article / Article
- 2025. ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR-/- hamsters. Genes Dis — PubMed:PMID39669548 | DOI:10.1016/j.gendis.2024.101379 — OMIA Phene_Article / Article
- 2025. Fat-1 ameliorates metabolic dysfunction-associated fatty liver disease and atherosclerosis through promoting the nuclear localization of PPARα in hamsters. Research (Wash D C) — PubMed:PMID40052160 | DOI:10.34133/research.0577 — OMIA Phene_Article / Article
- 2024. Development of a hamster model of spontaneous hypertriglyceridemia in diabetes. Animal Model Exp Med — PubMed:PMID39529532 | DOI:10.1002/ame2.12490 — OMIA Phene_Article / Article
- 2026. SiRNA-based inactivation of Angptl3 alleviates high-fat diet-induced MAFLD and atherosclerosis in LDLR-deficient hamsters. Lipids Health Dis — PubMed:PMID41787476 | DOI:10.1186/s12944-026-02916-3 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:143890 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:606945 (type: gene) — OMIA Group_OMIM (via OMIA_ID)