{"topic_id":"companion_species_health_omia_4226_hamster","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_omia_4226_hamster\ncategory: companion-species-health\ntitle: \"Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/hamster_omia_4226_4226.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_omia_4226_hamster/01_companion_species_health_omia_4226_hamster.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA000499/10036/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Mesocricetus auratus / Phodopus spp. (hamster)`\n- `Disorder: `\n- `Summary: Guo et al. (2018) \"generated Ldlr-ablated hamsters using CRISPR/Cas9 technology\". Thus these animals are genetically-modified organisms (GMO).`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 392710827 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2019. Dietary cholesterol is highly associated with severity of hyperlipidemia and atherosclerotic lesions in heterozygous LDLR-deficient hamsters. Int J Mol Sci — PubMed:PMID31323736 | DOI:10.3390/ijms20143515 — OMIA Phene_Article / Article\n- 2018. LDL receptor gene-ablated hamsters: A rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis. EBioMedicine — PubMed:PMID29289533 | DOI:10.1016/j.ebiom.2017.12.013 — OMIA Phene_Article / Article\n- 2021. Dietary-induced elevations of triglyceride-rich lipoproteins promote atherosclerosis in the low-density lipoprotein receptor knockout Syrian golden hamster. Front Cardiovasc Med — PubMed:PMID34796210 | DOI:10.3389/fcvm.2021.738060 — OMIA Phene_Article / Article\n- 2023. LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway. Toxicol Lett — PubMed:PMID37459939 | DOI:10.1016/j.toxlet.2023.07.009 — OMIA Phene_Article / Article\n- 2025. ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR-/- hamsters. Genes Dis — PubMed:PMID39669548 | DOI:10.1016/j.gendis.2024.101379 — OMIA Phene_Article / Article\n- 2025. Fat-1 ameliorates metabolic dysfunction-associated fatty liver disease and atherosclerosis through promoting the nuclear localization of PPARα in hamsters. Research (Wash D C) — PubMed:PMID40052160 | DOI:10.34133/research.0577 — OMIA Phene_Article / Article\n- 2024. Development of a hamster model of spontaneous hypertriglyceridemia in diabetes. Animal Model Exp Med — PubMed:PMID39529532 | DOI:10.1002/ame2.12490 — OMIA Phene_Article / Article\n- 2026. SiRNA-based inactivation of Angptl3 alleviates high-fat diet-induced MAFLD and atherosclerosis in LDLR-deficient hamsters. Lipids Health Dis — PubMed:PMID41787476 | DOI:10.1186/s12944-026-02916-3 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:143890 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606945 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Hamster — Hypercholesterolaemia (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/31323736/","retrieved":"","ref":"PMID 31323736","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":722,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}