Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)

--- license: permission_granted topic_id: companion_species_health_metabolic_syndrome_horse category: companion-species-health title: "Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/horse_metabolic_syndrome_3675.txt date_parsed: 2026-08-24 tokens_estimated: 121 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_metabolic_syndrome_horse/01_companion_species_health_metabolic_syndrome_horse.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001898/9796/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose." verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Species: Horse (Equus caballus)
• Disorder: Metabolic syndrome
• Summary: McGowan and Irland (2023): "Equine metabolic syndrome is not a disease, but a collection of risk factors for endocrinopathic laminitis with the defining feature of the syndrome being insulin dysregulation (ID) [Durham et al., 2018]. Risk factors for EMS include age, female sex, breed, being more sedentary and obesity [Durham et al., 2018; Carslake et al., 2021]."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2012. Diabetes, insulin resistance, and metabolic syndrome in horses. J Diabetes Sci Technol — PubMed:PMID22768883 | DOI:10.1177/193229681200600307 — OMIA Phene_Article / Article
• 2019. Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses. Equine Vet J — PubMed:PMID30472742 | DOI:10.1111/evj.13053 — OMIA Phene_Article / Article
• 2019. A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome. Vet J — PubMed:PMID31492392 | DOI:10.1016/j.tvjl.2019.105341 — OMIA Phene_Article / Article
• 2020. Preliminary analysis of the FAM174A gene suggests it lacks a strong association with equine metabolic syndrome in ponies. Domest Anim Endocrinol — PubMed:PMID32169753 | DOI:10.1016/j.domaniend.2020.106439 — OMIA Phene_Article / Article
• 2017. Genomewide association study reveals a risk locus for equine metabolic syndrome in the Arabian horse. J Anim Sci — PubMed:PMID28380523 | DOI:10.2527/jas.2016.1221 — OMIA Phene_Article / Article
• 2019. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) — PubMed:PMID31698676 | DOI:10.3390/genes10110893 — OMIA Phene_Article / Article
• 2019. Genetics of equine metabolic syndrome. Vet Rec — PubMed:PMID31371685 | DOI:10.1136/vr.l4725 — OMIA Phene_Article / Article
• 2015. Equine metabolic syndrome. Vet Rec — PubMed:PMID26273009 | DOI:10.1136/vr.103226 — OMIA Phene_Article / Article
• 2011. Equine metabolic syndrome. Vet Clin North Am Equine Pract — PubMed:PMID21392655 | DOI:10.1016/j.cveq.2010.12.004 — OMIA Phene_Article / Article
• 2010. Equine metabolic syndrome. J Vet Intern Med — PubMed:PMID20384947 | DOI:10.1111/j.1939-1676.2010.0503.x — OMIA Phene_Article / Article
• 2002. The equine metabolic syndrome peripheral Cushing's syndrome. Vet Clin North Am Equine Pract — PubMed:PMID15635908 | DOI:10.1016/s0749-0739(02)00006-8 — OMIA Phene_Article / Article
• 2020. The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes — PubMed:PMID33233816 | DOI:10.3390/genes11111378 — OMIA Phene_Article / Article
• (38 additional references in OMIA)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2012. Diabetes, insulin resistance, and metabolic syndrome in horses. J Diabetes Sci Technol — PubMed:PMID22768883 | DOI:10.1177/193229681200600307 — OMIA Phene_Article / Article
• 2019. Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses. Equine Vet J — PubMed:PMID30472742 | DOI:10.1111/evj.13053 — OMIA Phene_Article / Article
• 2019. A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome. Vet J — PubMed:PMID31492392 | DOI:10.1016/j.tvjl.2019.105341 — OMIA Phene_Article / Article
• 2020. Preliminary analysis of the FAM174A gene suggests it lacks a strong association with equine metabolic syndrome in ponies. Domest Anim Endocrinol — PubMed:PMID32169753 | DOI:10.1016/j.domaniend.2020.106439 — OMIA Phene_Article / Article
• 2017. Genomewide association study reveals a risk locus for equine metabolic syndrome in the Arabian horse. J Anim Sci — PubMed:PMID28380523 | DOI:10.2527/jas.2016.1221 — OMIA Phene_Article / Article
• 2019. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) — PubMed:PMID31698676 | DOI:10.3390/genes10110893 — OMIA Phene_Article / Article
• 2019. Genetics of equine metabolic syndrome. Vet Rec — PubMed:PMID31371685 | DOI:10.1136/vr.l4725 — OMIA Phene_Article / Article
• 2015. Equine metabolic syndrome. Vet Rec — PubMed:PMID26273009 | DOI:10.1136/vr.103226 — OMIA Phene_Article / Article
• 2011. Equine metabolic syndrome. Vet Clin North Am Equine Pract — PubMed:PMID21392655 | DOI:10.1016/j.cveq.2010.12.004 — OMIA Phene_Article / Article
• 2010. Equine metabolic syndrome. J Vet Intern Med — PubMed:PMID20384947 | DOI:10.1111/j.1939-1676.2010.0503.x — OMIA Phene_Article / Article
• 2002. The equine metabolic syndrome peripheral Cushing's syndrome. Vet Clin North Am Equine Pract — PubMed:PMID15635908 | DOI:10.1016/s0749-0739(02)00006-8 — OMIA Phene_Article / Article
• 2020. The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes — PubMed:PMID33233816 | DOI:10.3390/genes11111378 — OMIA Phene_Article / Article
• (38 additional references in OMIA)