{"topic_id":"companion_species_health_metabolic_syndrome_horse","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_metabolic_syndrome_horse\ncategory: companion-species-health\ntitle: \"Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/horse_metabolic_syndrome_3675.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 121\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_metabolic_syndrome_horse/01_companion_species_health_metabolic_syndrome_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001898/9796/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Horse (Equus caballus)`\n- `Disorder: Metabolic syndrome`\n- `Summary: McGowan and Irland (2023): \"Equine metabolic syndrome is not a disease, but a collection of risk factors for endocrinopathic laminitis with the defining feature of the syndrome being insulin dysregulation (ID) [Durham et al., 2018]. Risk factors for EMS include age, female sex, breed, being more sedentary and obesity [Durham et al., 2018; Carslake et al., 2021].\"`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2012. Diabetes, insulin resistance, and metabolic syndrome in horses. J Diabetes Sci Technol — PubMed:PMID22768883 | DOI:10.1177/193229681200600307 — OMIA Phene_Article / Article\n- 2019. Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses. Equine Vet J — PubMed:PMID30472742 | DOI:10.1111/evj.13053 — OMIA Phene_Article / Article\n- 2019. A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome. Vet J — PubMed:PMID31492392 | DOI:10.1016/j.tvjl.2019.105341 — OMIA Phene_Article / Article\n- 2020. Preliminary analysis of the FAM174A gene suggests it lacks a strong association with equine metabolic syndrome in ponies. Domest Anim Endocrinol — PubMed:PMID32169753 | DOI:10.1016/j.domaniend.2020.106439 — OMIA Phene_Article / Article\n- 2017. Genomewide association study reveals a risk locus for equine metabolic syndrome in the Arabian horse. J Anim Sci — PubMed:PMID28380523 | DOI:10.2527/jas.2016.1221 — OMIA Phene_Article / Article\n- 2019. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) — PubMed:PMID31698676 | DOI:10.3390/genes10110893 — OMIA Phene_Article / Article\n- 2019. Genetics of equine metabolic syndrome. Vet Rec — PubMed:PMID31371685 | DOI:10.1136/vr.l4725 — OMIA Phene_Article / Article\n- 2015. Equine metabolic syndrome. Vet Rec — PubMed:PMID26273009 | DOI:10.1136/vr.103226 — OMIA Phene_Article / Article\n- 2011. Equine metabolic syndrome. Vet Clin North Am Equine Pract — PubMed:PMID21392655 | DOI:10.1016/j.cveq.2010.12.004 — OMIA Phene_Article / Article\n- 2010. Equine metabolic syndrome. J Vet Intern Med — PubMed:PMID20384947 | DOI:10.1111/j.1939-1676.2010.0503.x — OMIA Phene_Article / Article\n- 2002. The equine metabolic syndrome peripheral Cushing's syndrome. Vet Clin North Am Equine Pract — PubMed:PMID15635908 | DOI:10.1016/s0749-0739(02)00006-8 — OMIA Phene_Article / Article\n- 2020. The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes — PubMed:PMID33233816 | DOI:10.3390/genes11111378 — OMIA Phene_Article / Article\n- (38 additional references in OMIA)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2012. Diabetes, insulin resistance, and metabolic syndrome in horses. J Diabetes Sci Technol — PubMed:PMID22768883 | DOI:10.1177/193229681200600307 — OMIA Phene_Article / Article\n- 2019. Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses. Equine Vet J — PubMed:PMID30472742 | DOI:10.1111/evj.13053 — OMIA Phene_Article / Article\n- 2019. A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome. Vet J — PubMed:PMID31492392 | DOI:10.1016/j.tvjl.2019.105341 — OMIA Phene_Article / Article\n- 2020. Preliminary analysis of the FAM174A gene suggests it lacks a strong association with equine metabolic syndrome in ponies. Domest Anim Endocrinol — PubMed:PMID32169753 | DOI:10.1016/j.domaniend.2020.106439 — OMIA Phene_Article / Article\n- 2017. Genomewide association study reveals a risk locus for equine metabolic syndrome in the Arabian horse. J Anim Sci — PubMed:PMID28380523 | DOI:10.2527/jas.2016.1221 — OMIA Phene_Article / Article\n- 2019. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) — PubMed:PMID31698676 | DOI:10.3390/genes10110893 — OMIA Phene_Article / Article\n- 2019. Genetics of equine metabolic syndrome. Vet Rec — PubMed:PMID31371685 | DOI:10.1136/vr.l4725 — OMIA Phene_Article / Article\n- 2015. Equine metabolic syndrome. Vet Rec — PubMed:PMID26273009 | DOI:10.1136/vr.103226 — OMIA Phene_Article / Article\n- 2011. Equine metabolic syndrome. Vet Clin North Am Equine Pract — PubMed:PMID21392655 | DOI:10.1016/j.cveq.2010.12.004 — OMIA Phene_Article / Article\n- 2010. Equine metabolic syndrome. J Vet Intern Med — PubMed:PMID20384947 | DOI:10.1111/j.1939-1676.2010.0503.x — OMIA Phene_Article / Article\n- 2002. The equine metabolic syndrome peripheral Cushing's syndrome. Vet Clin North Am Equine Pract — PubMed:PMID15635908 | DOI:10.1016/s0749-0739(02)00006-8 — OMIA Phene_Article / Article\n- 2020. The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes — PubMed:PMID33233816 | DOI:10.3390/genes11111378 — OMIA Phene_Article / Article\n- (38 additional references in OMIA)\n","sources":["companion-species-health — Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Horse (Equus caballus) — Metabolic syndrome (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/22768883/","retrieved":"","ref":"PMID 22768883","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1233,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}