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Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)

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--- license: permission_granted topic_id: companion_breed_health_nederlandse_kooikerhondje_omia3634_dog category: companion-breed-health title: "Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/nederlandse_kooikerhondje_omia3634_3634.txt date_parsed: 2026-08-02 tokens_estimated: 80 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_nederlandse_kooikerhondje_omia3634_dog/01_companion_breed_health_nederlandse_kooikerhondje_omia3634_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001874/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Nederlandse Kooikerhondje (Dog)
  • Disorder:
  • Summary: Opmeer et al. (2025): Polymyositis in the breed of ... Kooiker dogs is an autoimmune mediated inflammatory disease of skeletal muscles [with familial occurence].
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs.. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article
  • 2023. An inflammatory myopathy in the Dutch Kooiker dog.. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article
  • 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog.. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article
  • 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus.. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article
  • 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis.. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article
  • 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article
  • 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article
  • 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article
  • 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article
  • 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article
  • 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article
  • 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article
  • 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article
  • 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article
  • 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article
  • 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article
  • 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article
  • 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article
  • 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article
  • 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article
  • 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 23457575

Machine access

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