{"topic_id":"companion_breed_health_nederlandse_kooikerhondje_omia3634_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_nederlandse_kooikerhondje_omia3634_dog\ncategory: companion-breed-health\ntitle: \"Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/nederlandse_kooikerhondje_omia3634_3634.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_nederlandse_kooikerhondje_omia3634_dog/01_companion_breed_health_nederlandse_kooikerhondje_omia3634_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001874/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Nederlandse Kooikerhondje (Dog)`\n- `Disorder: `\n- `Summary: Opmeer et al. (2025): Polymyositis in the breed of ... Kooiker dogs is an autoimmune mediated inflammatory disease of skeletal muscles [with familial occurence].`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs.. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article\n- 2023. An inflammatory myopathy in the Dutch Kooiker dog.. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article\n- 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog.. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article\n- 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus.. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article\n- 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis.. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article\n- 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article\n- 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article\n- 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article\n- 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article\n- 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article\n- 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article\n- 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article\n- 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article\n- 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article\n- 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article\n- 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article\n- 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Association of an MHC class II haplotype with increased risk of polymyositis in Hungarian Vizsla dogs. PLoS One — PubMed:PMID23457575 | DOI:10.1371/journal.pone.0056490 — OMIA Phene_Article / Article\n- 2023. An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID37174546 | DOI:10.3390/ani13091508 — OMIA Phene_Article / Article\n- 2024. Pathologic changes in and immunophenotyping of polymyositis in the Dutch Kooiker dog. Animals (Basel) — PubMed:PMID39272303 | DOI:10.3390/ani14172519 — OMIA Phene_Article / Article\n- 2025. Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genet — PubMed:PMID39746095 | DOI:10.1371/journal.pgen.1011538 — OMIA Phene_Article / Article\n- 2025. Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis. Front Vet Sci — PubMed:PMID40520426 | DOI:10.3389/fvets.2025.1559040 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:160750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Nederlandse Kooikerhondje — Polymyositis (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/23457575/","retrieved":"","ref":"PMID 23457575","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1651,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}