Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_havanna_rabbit_omia3848_rabbit category: companion-breed-health title: "Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump." source_file: pdf-raw/breed-health/havanna_rabbit_omia3848_3848.txt date_parsed: 2026-08-23 tokens_estimated: 80 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-23 recovered: false path: companion-breed-health/companion_breed_health_havanna_rabbit_omia3848_rabbit/01_companion_breed_health_havanna_rabbit_omia3848_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001249/9986/" retrieved: "2026-08-23" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Havanna (Rabbit)
• Disorder:
• Mode of inheritance: Autosomal recessive
• Summary: See Robinson (1958, p. 238)
• Defect: no

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: TRP-1 (Entrez Gene ID 389108532) — OMIA Phene_Gene / GeneSynonym
• OMIA molecular-genetics note: Utzer et al. (2014): "A mutation in exon 2 (g.41360196G>A) leads to a premature stop codon at position 190 of the deduced amino acid sequence (p.Trp190ter). Therefore, translation predicts a truncated TYRP1 protein lacking almost completely the tyrosinase domain."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article
• 2014. A premature stop codon in the TYRP1 gene is associated with brown coat colour in the European rabbit (Oryctolagus cuniculus). Anim Genet — PubMed:PMID24814776 | DOI:10.1111/age.12171 — OMIA Phene_Article / Article
• 1924. On the Occurrence in Rabbits of Linkage in Inheritance between Albinism and Brown Pigmentation. Proc Natl Acad Sci U S A — PubMed:PMID16576859 | DOI:10.1073/pnas.10.12.486 — OMIA Phene_Article / Article
• 2021. Rabbits - their domestication and molecular genetics of hair coat development and quality. Anim Genet — PubMed:PMID33216407 | DOI:10.1111/age.13024 — OMIA Phene_Article / Article
• 2021. Analysis of MC1R, MITF, TYR, TYRP1, and MLPH genes polymorphism in four rabbit breeds with different coat colors. Animals (Basel) — PubMed:PMID33466315 | DOI:10.3390/ani11010081 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:612271 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:203290 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:115501 (type: gene) — OMIA Group_OMIM (via OMIA_ID)