{"topic_id":"companion_breed_health_havanna_rabbit_omia3848_rabbit","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_havanna_rabbit_omia3848_rabbit\ncategory: companion-breed-health\ntitle: \"Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/havanna_rabbit_omia3848_3848.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_havanna_rabbit_omia3848_rabbit/01_companion_breed_health_havanna_rabbit_omia3848_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001249/9986/\"\n  retrieved: \"2026-08-23\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Havanna (Rabbit)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal recessive`\n- `Summary: See Robinson (1958, p. 238)`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: TRP-1 (Entrez Gene ID 389108532) — OMIA Phene_Gene / GeneSynonym\n- OMIA molecular-genetics note: Utzer et al. (2014): \"A mutation in exon 2 (g.41360196G>A) leads to a premature stop codon at position 190 of the deduced amino acid sequence (p.Trp190ter). Therefore, translation predicts a truncated TYRP1 protein lacking almost completely the tyrosinase domain.\"\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 2014. A premature stop codon in the TYRP1 gene is associated with brown coat colour in the European rabbit (Oryctolagus cuniculus). Anim Genet — PubMed:PMID24814776 | DOI:10.1111/age.12171 — OMIA Phene_Article / Article\n- 1924. On the Occurrence in Rabbits of Linkage in Inheritance between Albinism and Brown Pigmentation. Proc Natl Acad Sci U S A — PubMed:PMID16576859 | DOI:10.1073/pnas.10.12.486 — OMIA Phene_Article / Article\n- 2021. Rabbits - their domestication and molecular genetics of hair coat development and quality. Anim Genet — PubMed:PMID33216407 | DOI:10.1111/age.13024 — OMIA Phene_Article / Article\n- 2021. Analysis of MC1R, MITF, TYR, TYRP1, and MLPH genes polymorphism in four rabbit breeds with different coat colors. Animals (Basel) — PubMed:PMID33466315 | DOI:10.3390/ani11010081 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:612271 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:203290 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:115501 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Havanna (Rabbit) — Coat colour, brown, TYRP1-related (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/24814776/","retrieved":"","ref":"PMID 24814776","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":678,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}