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Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)

companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog

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--- license: permission_granted topic_id: companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog category: companion-breed-health title: "Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/golden_retriever_hereditary_spectrin_deficiency_2755.txt date_parsed: 2026-08-02 tokens_estimated: 219 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog/01_companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001228/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Golden Retriever (Dog)
  • Disorder: Hereditary spectrin deficiency
  • Mode of inheritance: Autosomal dominant
  • Summary: Slappendel et al. (2005) were the first to describe hereditary spectrin deficiency in dogs: A radioimmunoassay revealed that erythrocyte spectrin concentration was 50-65% of normal in 5 adult Golden Retriever dogs, which had recovered from hemolytic anemia but whose OF [osmotic fragility] had persistently remained increased. OF also was increased and spectrin concentration was decreased (60-73%) in 10 dogs of an apparently healthy family of 19 Golden Retrievers related to a proband. Pedigree analysis revealed autosomal dominant inheritance. ... It is not clear whether spectrin deficiency in Golden Retrievers may result in hemolytic anemia, as in humans.
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2005. Hereditary spectrin deficiency in Golden Retriever dogs.. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article
  • 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog.. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article
  • 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia.. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article
  • 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article
  • 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article
  • 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article
  • 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article
  • 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article
  • 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article
  • 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article
  • 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 15822562

Machine access

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