{"topic_id":"companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog\ncategory: companion-breed-health\ntitle: \"Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/golden_retriever_hereditary_spectrin_deficiency_2755.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 219\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog/01_companion_breed_health_golden_retriever_hereditary_spectrin_deficiency_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001228/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Golden Retriever (Dog)`\n- `Disorder: Hereditary spectrin deficiency`\n- `Mode of inheritance: Autosomal dominant`\n- `Summary: Slappendel et al. (2005) were the first to describe hereditary spectrin deficiency in dogs: A radioimmunoassay revealed that erythrocyte spectrin concentration was 50-65% of normal in 5 adult Golden Retriever dogs, which had recovered from hemolytic anemia but whose OF [osmotic fragility] had persistently remained increased. OF also was increased and spectrin concentration was decreased (60-73%) in 10 dogs of an apparently healthy family of 19 Golden Retrievers related to a proband. Pedigree analysis revealed autosomal dominant inheritance. ... It is not clear whether spectrin deficiency in Golden Retrievers may result in hemolytic anemia, as in humans.`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2005. Hereditary spectrin deficiency in Golden Retriever dogs.. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article\n- 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog.. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article\n- 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia.. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article\n- 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article\n- 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article\n- 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article\n- 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article\n- 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article\n- 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2005. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med — PubMed:PMID15822562 — OMIA Phene_Article / Article\n- 2022. Exertional hemolysis and hematuria in a Labrador Retriever dog. J Vet Diagn Invest — PubMed:PMID36184929 | DOI:10.1177/10406387221127268 — OMIA Phene_Article / Article\n- 2023. Detection of spherocytosis in dogs with immune-mediated hemolytic anemia. Vet Clin Pathol — PubMed:PMID37272477 | DOI:10.1111/vcp.13235 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:109270 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:182900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612653 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Golden Retriever — Hereditary spectrin deficiency (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/15822562/","retrieved":"","ref":"PMID 15822562","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1439,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}