Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_giant_schnauzer_omia3473_dog category: companion-breed-health title: "Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/giant_schnauzer_omia3473_3473.txt date_parsed: 2026-08-02 tokens_estimated: 122 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_giant_schnauzer_omia3473_dog/01_companion_breed_health_giant_schnauzer_omia3473_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001787/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Giant Schnauzer (Dog)
• Disorder:
• Mode of inheritance: Multifactorial
• Clin feat: As summarised by Karyadi et al. (2013), SCCD is a locally aggressive cancer that causes lytic bone lesions, sometimes with multiple toe recurrence.
• Defect: yes
• Prevalence: As mentioned above, only dark-coloured Standard Poodles are susceptible; light-coloured dogs of the same breed are rarely affected.

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: 710-712 (Entrez Gene ID 388199034) — OMIA Phene_Gene / GeneSynonym

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1983. [Squamous cell carcinoma of the toes in dogs]. Dtsch Tierarztl Wochenschr — PubMed:PMID6354679 — OMIA Phene_Article / Article
• 1984. Basal- and squamous-cell neoplasms of dogs and cats. Am J Dermatopathol — PubMed:PMID6731733 | DOI:10.1097/00000372-198404000-00017 — OMIA Phene_Article / Article
• 1992. Treatment by digital amputation of subungual squamous cell carcinoma in dogs: 21 cases (1987-1988). J Am Vet Med Assoc — PubMed:PMID1399782 — OMIA Phene_Article / Article
• 1995. Evaluation of dogs with digit masses: 117 cases (1981-1991). J Am Vet Med Assoc — PubMed:PMID7657570 — OMIA Phene_Article / Article
• 2005. Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs. J Vet Intern Med — PubMed:PMID16231717 | DOI:10.1892/0891-6640(2005)19[720:cdtavc]2.0.co;2 — OMIA Phene_Article / Article
• 2007. Agreement among surgical pathologists evaluating routine histologic sections of digits amputated from cats and dogs. J Vet Diagn Invest — PubMed:PMID17609360 | DOI:10.1177/104063870701900420 — OMIA Phene_Article / Article
• 1989. Squamous cell carcinoma of the nail bed in three related giant schnauzers. Vet Rec — PubMed:PMID2800263 | DOI:10.1136/vr.125.12.322 — OMIA Phene_Article / Article
• 2008. Tumors of the Skin and Soft Tissues. In:. Tumors in Domestic Animals. Meuten DJ, editor. Ames, Iowa: Iowa State University Press — OMIA Phene_Article / Article
• 2013. A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit. PLoS Genet — PubMed:PMID23555311 | DOI:10.1371/journal.pgen.1003409 — OMIA Phene_Article / Article
• 2014. Domestic dogs and cancer research: a breed-based genomics approach. ILAR J — PubMed:PMID24936030 | DOI:10.1093/ilar/ilu017 — OMIA Phene_Article / Article
• 2016. Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs. Proc Natl Acad Sci U S A — PubMed:PMID26699508 | DOI:10.1073/pnas.1512501113 — OMIA Phene_Article / Article
• 2023. KITLG copy number germline variations in Schnauzer breeds and their relevance in digital squamous cell carcinoma in black giant Schnauzers. Vet Sci — PubMed:PMID36851451 | DOI:10.3390/vetsci10020147 — OMIA Phene_Article / Article
• (2 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:184745 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."