{"topic_id":"companion_breed_health_giant_schnauzer_omia3473_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_giant_schnauzer_omia3473_dog\ncategory: companion-breed-health\ntitle: \"Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/giant_schnauzer_omia3473_3473.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 122\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_giant_schnauzer_omia3473_dog/01_companion_breed_health_giant_schnauzer_omia3473_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001787/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Giant Schnauzer (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Multifactorial`\n- `Clin feat: As summarised by Karyadi et al. (2013), SCCD is a locally aggressive cancer that causes lytic bone lesions, sometimes with multiple toe recurrence.`\n- `Defect: yes`\n- `Prevalence: As mentioned above, only dark-coloured Standard Poodles are susceptible; light-coloured dogs of the same breed are rarely affected.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: 710-712 (Entrez Gene ID 388199034) — OMIA Phene_Gene / GeneSynonym\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1983. [Squamous cell carcinoma of the toes in dogs]. Dtsch Tierarztl Wochenschr — PubMed:PMID6354679 — OMIA Phene_Article / Article\n- 1984. Basal- and squamous-cell neoplasms of dogs and cats. Am J Dermatopathol — PubMed:PMID6731733 | DOI:10.1097/00000372-198404000-00017 — OMIA Phene_Article / Article\n- 1992. Treatment by digital amputation of subungual squamous cell carcinoma in dogs: 21 cases (1987-1988). J Am Vet Med Assoc — PubMed:PMID1399782 — OMIA Phene_Article / Article\n- 1995. Evaluation of dogs with digit masses: 117 cases (1981-1991). J Am Vet Med Assoc — PubMed:PMID7657570 — OMIA Phene_Article / Article\n- 2005. Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs. J Vet Intern Med — PubMed:PMID16231717 | DOI:10.1892/0891-6640(2005)19[720:cdtavc]2.0.co;2 — OMIA Phene_Article / Article\n- 2007. Agreement among surgical pathologists evaluating routine histologic sections of digits amputated from cats and dogs. J Vet Diagn Invest — PubMed:PMID17609360 | DOI:10.1177/104063870701900420 — OMIA Phene_Article / Article\n- 1989. Squamous cell carcinoma of the nail bed in three related giant schnauzers. Vet Rec — PubMed:PMID2800263 | DOI:10.1136/vr.125.12.322 — OMIA Phene_Article / Article\n- 2008. Tumors of the Skin and Soft Tissues. In:. Tumors in Domestic Animals. Meuten DJ, editor. Ames, Iowa: Iowa State University Press — OMIA Phene_Article / Article\n- 2013. A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit. PLoS Genet — PubMed:PMID23555311 | DOI:10.1371/journal.pgen.1003409 — OMIA Phene_Article / Article\n- 2014. Domestic dogs and cancer research: a breed-based genomics approach. ILAR J — PubMed:PMID24936030 | DOI:10.1093/ilar/ilu017 — OMIA Phene_Article / Article\n- 2016. Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs. Proc Natl Acad Sci U S A — PubMed:PMID26699508 | DOI:10.1073/pnas.1512501113 — OMIA Phene_Article / Article\n- 2023. KITLG copy number germline variations in Schnauzer breeds and their relevance in digital squamous cell carcinoma in black giant Schnauzers. Vet Sci — PubMed:PMID36851451 | DOI:10.3390/vetsci10020147 — OMIA Phene_Article / Article\n- (2 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:184745 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Giant Schnauzer — Squamous cell carcinoma of the digit (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/6354679/","retrieved":"","ref":"PMID 6354679","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":907,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}