← All Topics / companion-breed-health

German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)

companion_breed_health_german_shepherd_dog_omia3116_dog

companion-breed-health en

--- license: permission_granted topic_id: companion_breed_health_german_shepherd_dog_omia3116_dog category: companion-breed-health title: "German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/german_shepherd_dog_omia3116_3116.txt date_parsed: 2026-08-02 tokens_estimated: 94 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_german_shepherd_dog_omia3116_dog/01_companion_breed_health_german_shepherd_dog_omia3116_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001589/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: German Shepherd Dog (Dog)
  • Disorder:
  • Defect: yes
  • Gen test: The Kennel Club's list of genetic tests (http://www.thekennelclub.org.uk/download/8288/DNA-Tests-Worldwide-2.pdf) includes an indirect DNA test for this disorder, based on the MHC association reported by Kennedy et al. (2008).

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs.. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article
  • 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*.. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article
  • 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy.. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article
  • 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex.. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article
  • 2014. Genetics of canine anal furunculosis in the German shepherd dog.. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article
  • 1973. The management of anal furunculosis.. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article
  • 1980. Anal furunculosis: a review of seventy cases.. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article
  • 1980. Canine anal furunculosis: a modified approach.. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article
  • 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article
  • 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article
  • 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article
  • 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article
  • 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article
  • 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article
  • 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article
  • 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article
  • 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article
  • 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article
  • 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article
  • 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article
  • 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article
  • 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article
  • 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article
  • 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article
  • 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article
  • 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article
  • 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article
  • 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article
  • 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article
  • 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article
  • 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article
  • 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article
  • 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article
  • 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article
  • 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article
  • 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article
  • 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article
  • 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article
  • 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 19254256

Machine access

AI agents: this page mirrors GET /api/v1/llm_context?topic=companion_breed_health_german_shepherd_dog_omia3116_dog (max 500 tokens, whitelisted). Rate limit 60 req/min for recognized AI crawlers.

Raw JSON ↗ llm.txt OpenAPI