{"topic_id":"companion_breed_health_german_shepherd_dog_omia3116_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_german_shepherd_dog_omia3116_dog\ncategory: companion-breed-health\ntitle: \"German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/german_shepherd_dog_omia3116_3116.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 94\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_german_shepherd_dog_omia3116_dog/01_companion_breed_health_german_shepherd_dog_omia3116_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001589/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: German Shepherd Dog (Dog)`\n- `Disorder: `\n- `Defect: yes`\n- `Gen test: The Kennel Club's list of genetic tests (http://www.thekennelclub.org.uk/download/8288/DNA-Tests-Worldwide-2.pdf) includes an indirect DNA test for this disorder, based on the MHC association reported by Kennedy et al. (2008).`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs.. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article\n- 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*.. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article\n- 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy.. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article\n- 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex.. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article\n- 2014. Genetics of canine anal furunculosis in the German shepherd dog.. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article\n- 1973. The management of anal furunculosis.. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article\n- 1980. Anal furunculosis: a review of seventy cases.. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article\n- 1980. Canine anal furunculosis: a modified approach.. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article\n- 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article\n- 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis.. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article\n- 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article\n- 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article\n- 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article\n- 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article\n- 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article\n- 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article\n- 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article\n- 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article\n- 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article\n- 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article\n- 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article\n- 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article\n- 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article\n- 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article\n- 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article\n- 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article\n- 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article\n- 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article\n- 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article\n- 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article\n- 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2009. Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens — PubMed:PMID19254256 | DOI:10.1111/j.1399-0039.2008.01190.x — OMIA Phene_Article / Article\n- 2009. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens — PubMed:PMID19254251 | DOI:10.1111/j.1399-0039.2008.01188.x — OMIA Phene_Article / Article\n- 2008. Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol — PubMed:PMID18541310 | DOI:10.1016/j.vetimm.2008.04.018 — OMIA Phene_Article / Article\n- 2008. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens — PubMed:PMID17999655 | DOI:10.1111/j.1399-0039.2007.00964.x — OMIA Phene_Article / Article\n- 2014. Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics — PubMed:PMID24626934 | DOI:10.1007/s00251-014-0766-5 — OMIA Phene_Article / Article\n- 1973. The management of anal furunculosis. J Small Anim Pract — PubMed:PMID4803921 | DOI:10.1111/j.1748-5827.1973.tb06467.x — OMIA Phene_Article / Article\n- 1980. Anal furunculosis: a review of seventy cases. J Small Anim Pract — PubMed:PMID7230744 | DOI:10.1111/j.1748-5827.1980.tb01359.x — OMIA Phene_Article / Article\n- 1980. Canine anal furunculosis: a modified approach. J Small Anim Pract — PubMed:PMID7230745 | DOI:10.1111/j.1748-5827.1980.tb01360.x — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3195021 | DOI:10.1136/vr.123.13.355-b — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201692 | DOI:10.1136/vr.123.17.452 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3201701 | DOI:10.1136/vr.123.19.499 — OMIA Phene_Article / Article\n- 1988. Anal furunculosis. Vet Rec — PubMed:PMID3206811 | DOI:10.1136/vr.123.21.555-a — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"German Shepherd Dog — Anal furunculosis (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/19254256/","retrieved":"","ref":"PMID 19254256","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2243,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}