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German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)

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--- license: permission_granted topic_id: companion_breed_health_german_shepherd_dog_omia1384_dog category: companion-breed-health title: "German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/german_shepherd_dog_omia1384_1384.txt date_parsed: 2026-08-02 tokens_estimated: 154 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_german_shepherd_dog_omia1384_dog/01_companion_breed_health_german_shepherd_dog_omia1384_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000754/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: German Shepherd Dog (Dog)
  • Disorder:
  • Mode of inheritance: Autosomal dominant
  • Summary: See also entries for osteogenesis imperfecta for which likely causal variants have been identified, e.g., a href=../../../../../../OMIA002112/9615/OMIA:002112-9615/a Osteogenesis imperfecta, COL1A2-related'; 'a href=../../../../../../OMIA001483/9615/OMIA:001483-9615/a Osteogenesis imperfecta, SERPINH1-related' and 'a href=../../../../../../OMIA002126/9615/OMIA:002126-9615/a Osteogenesis imperfecta, type III, COL1A1-related'
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article
  • 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden.. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article
  • 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy.. Kleintierpraxis — OMIA Phene_Article / Article
  • 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article
  • 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article
  • 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies.. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article
  • 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff.. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article
  • 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article
  • 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article
  • 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article
  • 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article
  • 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article
  • 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article
  • 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article
  • 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article
  • 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article
  • 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article
  • 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article
  • 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article
  • 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article
  • 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article
  • 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article
  • 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article
  • 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article
  • 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article
  • 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article
  • 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article
  • 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article
  • 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article
  • 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article
  • 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 9227748

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