{"topic_id":"companion_breed_health_german_shepherd_dog_omia1384_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_german_shepherd_dog_omia1384_dog\ncategory: companion-breed-health\ntitle: \"German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/german_shepherd_dog_omia1384_1384.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 154\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_german_shepherd_dog_omia1384_dog/01_companion_breed_health_german_shepherd_dog_omia1384_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000754/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: German Shepherd Dog (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal dominant`\n- `Summary: See also entries for osteogenesis imperfecta for which likely causal variants have been identified, e.g., a href=../../../../../../OMIA002112/9615/OMIA:002112-9615/a Osteogenesis imperfecta, COL1A2-related'; 'a href=../../../../../../OMIA001483/9615/OMIA:001483-9615/a Osteogenesis imperfecta, SERPINH1-related' and 'a href=../../../../../../OMIA002126/9615/OMIA:002126-9615/a Osteogenesis imperfecta, type III, COL1A1-related'`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article\n- 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden.. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article\n- 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy.. Kleintierpraxis — OMIA Phene_Article / Article\n- 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article\n- 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article\n- 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies.. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article\n- 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff.. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article\n- 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article\n- 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article\n- 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article\n- 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article\n- 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article\n- 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article\n- 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article\n- 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article\n- 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article\n- 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article\n- 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article\n- 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article\n- 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article\n- 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article\n- 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article\n- 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article\n- 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article\n- 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1956. Idiopathic familial osteoporosis in dogs: 'Osteogenesis imperfecta'. Annals of the New York Academy of Sciences — OMIA Phene_Article / Article\n- 1960. [Contribution to the clinical picture and pathology of Osteogenesis imperfecta in the young dog.] Beitrag zur Klinik und Pathologie der Osteogenesis imperfecta bei Junghunden. Zentralblatt fur Veterinarmedizin — OMIA Phene_Article / Article\n- 1991. Case report - Osteogenesis imperfecta in a German Shepherd puppy. Kleintierpraxis — OMIA Phene_Article / Article\n- 1997. Clinical signs and diagnosis of osteogenesis imperfecta in three dogs. J Am Vet Med Assoc — PubMed:PMID9227748 — OMIA Phene_Article / Article\n- 2000. Osteogenesis imperfecta in three dogs from a single litter. Veterinary & Comparative Orthopaedics & Traumatology — OMIA Phene_Article / Article\n- 2021. Osteogenesis imperfecta in two Finnish Lapphund puppies. Vet Med (Auckl) — PubMed:PMID34168973 | DOI:10.2147/VMRR.S308418 — OMIA Phene_Article / Article\n- 2019. Osteogenesis and dentinogenesis imperfecta in a four-month-old English mastiff. Veterinary Record Case Reports — DOI:10.1136/vetreccr-2019-000835 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:166210 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:166220 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259420 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:259440 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"German Shepherd Dog — Osteogenesis imperfecta, generic (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/9227748/","retrieved":"","ref":"PMID 9227748","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2041,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}