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Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)

companion_breed_health_dalmatian_omia4239_dog

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--- license: permission_granted topic_id: companion_breed_health_dalmatian_omia4239_dog category: companion-breed-health title: "Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/dalmatian_omia4239_4239.txt date_parsed: 2026-08-02 tokens_estimated: 242 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_dalmatian_omia4239_dog/01_companion_breed_health_dalmatian_omia4239_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002214/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Dalmatian (Dog)
  • Disorder:
  • Mode of inheritance: Bjerkås (1977): The disease is probably transmitted by autosomal recessive inheritance.
  • Clin feat: Bjerkås (1977): The symptoms started at the age of 3-6 months and were dominated by visual deficiency and/or progressive locomotive abnormalities.
  • Defect: yes
  • Pathology: Bjerkås (1977): the most consistent lesions were found bilaterally in the region of the centrum semiovale. The optic nerves were also frequently affected, the basal ganglia and spinal cord were affected infrequently. The main lesions were confined to myelin, while axons and nerve cells were spared, particularly in the early stages of the lesions. Numerous phagocytes were observed which contained engulfed myelin and other lipid breakdown products. Ultrastructurally and histochemically the disease differs from previously described types of leucodystrophy.

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article
  • 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article
  • 1977. Hereditary "cavitating" leucodystrophy in Dalmation dogs. Light and electron microscopic studies.. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article
  • 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article
  • 1977. Hereditary "cavitating" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article
  • 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article
  • 1977. Hereditary "cavitating" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article
  • 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article
  • 1977. Hereditary "cavitating" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article
  • 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article
  • 1977. Hereditary "cavitating" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 930564

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