{"topic_id":"companion_breed_health_dalmatian_omia4239_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_dalmatian_omia4239_dog\ncategory: companion-breed-health\ntitle: \"Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/dalmatian_omia4239_4239.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 242\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_dalmatian_omia4239_dog/01_companion_breed_health_dalmatian_omia4239_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002214/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Dalmatian (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Bjerkås (1977): The disease is probably transmitted by autosomal recessive inheritance.`\n- `Clin feat: Bjerkås (1977): The symptoms started at the age of 3-6 months and were dominated by visual deficiency and/or progressive locomotive abnormalities.`\n- `Defect: yes`\n- `Pathology: Bjerkås (1977): the most consistent lesions were found bilaterally in the region of the centrum semiovale. The optic nerves were also frequently affected, the basal ganglia and spinal cord were affected infrequently. The main lesions were confined to myelin, while axons and nerve cells were spared, particularly in the early stages of the lesions. Numerous phagocytes were observed which contained engulfed myelin and other lipid breakdown products. Ultrastructurally and histochemically the disease differs from previously described types of leucodystrophy.`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article\n- 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article\n- 1977. Hereditary \"cavitating\" leucodystrophy in Dalmation dogs. Light and electron microscopic studies.. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article\n- 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article\n- 1977. Hereditary \"cavitating\" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article\n- 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article\n- 1977. Hereditary \"cavitating\" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article\n- 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article\n- 1977. Hereditary \"cavitating\" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1974. Hereditary myelin defect in Dalmatian dogs in Norway. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik — OMIA Phene_Article / Article\n- 1979. Hereditary leukodystrophy in Dalmatian dogs in Norway. Norsk Veterinaertidsskrift — OMIA Phene_Article / Article\n- 1977. Hereditary \"cavitating\" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol — PubMed:PMID930564 | DOI:10.1007/bf00688706 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Dalmatian — Leukodystrophy, cavitating (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/930564/","retrieved":"","ref":"PMID 930564","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1056,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}