Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_basset_hound_omia3513_dog category: companion-breed-health title: "Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/basset_hound_omia3513_3513.txt date_parsed: 2026-08-02 tokens_estimated: 182 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_basset_hound_omia3513_dog/01_companion_breed_health_basset_hound_omia3513_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001806/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Basset Hound (Dog)
• Disorder:
• Mode of inheritance: Autosomal recessive
• Summary: Dreger et al. (2013) identified a duplication in an intron of the RALY gene encoding hnRNP associated with lethal yellow that discriminated black-and-tan and saddle tan Basset Hounds and Pembroke Welsh Corgis. The RALY gene is located upstream of ASIP and the intronic duplication is in linkage disequilibrium with the likely causal variant in the ventral promoter of ASIP identified by Bannasch et al. (2021). For more detail on the likely causal variant in the ASIP promoter see OMIA 000201-9615 : Coat colour, agouti in Canis lupus familiaris
• Defect: no

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: agouti (Entrez Gene ID 492296) — OMIA Phene_Gene / GeneSynonym

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2013. Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered — PubMed:PMID23519866 | DOI:10.1093/jhered/est012 — OMIA Phene_Article / Article
• 2019. True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential. PLoS One — PubMed:PMID31658272 | DOI:10.1371/journal.pone.0223995 — OMIA Phene_Article / Article
• 2021. Genomic regions associated with variation in pigmentation loss in saddle tan Beagles. Genes (Basel) — PubMed:PMID33672409 | DOI:10.3390/genes12020316 — OMIA Phene_Article / Article
• 2021. Dog colour patterns explained by modular promoters of ancient canid origin. Nat Ecol Evol — PubMed:PMID34385618 | DOI:10.1038/s41559-021-01524-x — OMIA Phene_Article / Article
• 2023. Analysis of Doberman Pinscher and Toy Poodle samples with targeted next-generation sequencing. Gene — PubMed:PMID36427679 | DOI:10.1016/j.gene.2022.147069 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:600201 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."