{"topic_id":"companion_breed_health_basset_hound_omia3513_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_basset_hound_omia3513_dog\ncategory: companion-breed-health\ntitle: \"Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/basset_hound_omia3513_3513.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 182\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_basset_hound_omia3513_dog/01_companion_breed_health_basset_hound_omia3513_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001806/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Basset Hound (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal recessive`\n- `Summary: Dreger et al. (2013) identified a duplication in an intron of the RALY gene encoding hnRNP associated with lethal yellow that discriminated black-and-tan and saddle tan Basset Hounds and Pembroke Welsh Corgis. The RALY gene is located upstream of ASIP and the intronic duplication is in linkage disequilibrium with the likely causal variant in the ventral promoter of ASIP identified by Bannasch et al. (2021). For more detail on the likely causal variant in the ASIP promoter see OMIA 000201-9615 : Coat colour, agouti in Canis lupus familiaris`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: agouti (Entrez Gene ID 492296) — OMIA Phene_Gene / GeneSynonym\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered — PubMed:PMID23519866 | DOI:10.1093/jhered/est012 — OMIA Phene_Article / Article\n- 2019. True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential. PLoS One — PubMed:PMID31658272 | DOI:10.1371/journal.pone.0223995 — OMIA Phene_Article / Article\n- 2021. Genomic regions associated with variation in pigmentation loss in saddle tan Beagles. Genes (Basel) — PubMed:PMID33672409 | DOI:10.3390/genes12020316 — OMIA Phene_Article / Article\n- 2021. Dog colour patterns explained by modular promoters of ancient canid origin. Nat Ecol Evol — PubMed:PMID34385618 | DOI:10.1038/s41559-021-01524-x — OMIA Phene_Article / Article\n- 2023. Analysis of Doberman Pinscher and Toy Poodle samples with targeted next-generation sequencing. Gene — PubMed:PMID36427679 | DOI:10.1016/j.gene.2022.147069 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:600201 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Basset Hound — Coat colour, saddle tan vs black-and-tan (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/23519866/","retrieved":"","ref":"PMID 23519866","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":721,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}