FDA ADE — Top Reported Active Ingredients in Dogs
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level and not additive. This topic ranks the active ingredients most frequently named in adverse-event reports where the affected animal species is Dog. Active-ingredient names are verbatim from openFDA's drug.active_ingredients.name field (combo products appear as combined terms, e.g. "Pyrantel Pamoate;Sarolaner").
Total Dog adverse-event reports
Dog: 985705
Top reported active ingredients (Dog)
- Spinosad 180156
- Milbemycin Oxime 168422
- Ivermectin 103618
- Pyrantel As Pamoate Salt 82225
- Moxidectin 59458
- Pyrantel Pamoate;Sarolaner 50473
- Afoxolaner 49881
- Carprofen 46231
- Praziquantel 40031
- Ivermectin, Pyrantel 34870
- Fluralaner Chew Tablets 32050
- Selamectin 29364
- Oclacitinib Maleate 27588
- Fluralaner 13.64% 12-Week Chew 26255
- Milbemycin 21503
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_species_active_2026-07-22.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).