{"topic_id":"ade_top_actives_dog","category":"ade","context":"---\ntopic_id: ade_top_actives_dog\ncategory: ade\ntitle: \"FDA ADE — top reported active ingredients in Dogs\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-22\"\nsource_file: pdf-raw/ade/ade_species_active_2026-07-22.json\ndate_parsed: 2026-07-22\ntokens_estimated: 220\nverification:\n  method: substring_match\n  claims: 16\n  passed: 16\n  date: 2026-07-22\n---\n\n# FDA ADE — Top Reported Active Ingredients in Dogs\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level and not additive. This topic ranks the active ingredients most frequently named in adverse-event reports where the affected animal species is **Dog**. Active-ingredient names are verbatim from openFDA's `drug.active_ingredients.name` field (combo products appear as combined terms, e.g. \"Pyrantel Pamoate;Sarolaner\").\n\n## Total Dog adverse-event reports\nDog: 985705\n\n## Top reported active ingredients (Dog)\n- Spinosad 180156\n- Milbemycin Oxime 168422\n- Ivermectin 103618\n- Pyrantel As Pamoate Salt 82225\n- Moxidectin 59458\n- Pyrantel Pamoate;Sarolaner 50473\n- Afoxolaner 49881\n- Carprofen 46231\n- Praziquantel 40031\n- Ivermectin, Pyrantel 34870\n- Fluralaner Chew Tablets 32050\n- Selamectin 29364\n- Oclacitinib Maleate 27588\n- Fluralaner 13.64% 12-Week Chew 26255\n- Milbemycin 21503\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_species_active_2026-07-22.json` (openFDA animalandveterinary/event.json, pulled 2026-07-22).\n","sources":[],"tokens_estimated":220,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}