selamectin — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. selamectin is a macrocyclic lactone (endectocide: flea/tick/heartworm).
Total reports
selamectin: 71507
Reports by species (top entries)
- Cat 29765
- Dog 29419
- Human 2303
- Other 294
- Rabbit 103
- Ferret 36
Top reported reactions (VEDDRA terms, top entries)
- INEFFECTIVE, HEARTWORM LARVAE 8169
- Application site alopecia 6462
- Lack of efficacy (ectoparasite) - flea 6307
- Vomiting 5741
- Underfilling, Tubes 4636
- Application site hair loss 4533
- Anorexia 3699
- Depression 3587
- Diarrhoea 2993
- Lethargy (see also Central nervous system depression in 'Neurological') 2939
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).