{"topic_id":"ade_selamectin_adverse_events","category":"ade","context":"---\ntopic_id: ade_selamectin_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for selamectin (macrocyclic lactone (endectocide: flea/tick/heartworm)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 202\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-21\n---\n\n# selamectin — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. selamectin is a macrocyclic lactone (endectocide: flea/tick/heartworm).\n\n## Total reports\nselamectin: 71507\n\n## Reports by species (top entries)\n- Cat 29765\n- Dog 29419\n- Human 2303\n- Other 294\n- Rabbit 103\n- Ferret 36\n\n## Top reported reactions (VEDDRA terms, top entries)\n- INEFFECTIVE, HEARTWORM LARVAE 8169\n- Application site alopecia 6462\n- Lack of efficacy (ectoparasite) - flea 6307\n- Vomiting 5741\n- Underfilling, Tubes 4636\n- Application site hair loss 4533\n- Anorexia 3699\n- Depression 3587\n- Diarrhoea 2993\n- Lethargy (see also Central nervous system depression in 'Neurological') 2939\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":202,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}