(S)-Methoprene — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. (S)-Methoprene is a active ingredient.
Total reports
(S)-Methoprene: 1671
Reports by species (top entries)
- Dog 1603
- Human 27
- Cat 11
- Other 8
Top reported reactions (VEDDRA terms, top entries)
- Depression 542
- Vomiting 454
- Ataxia 433
- Anorexia 189
- Trembling 150
- Lack of efficacy (ectoparasite) - flea 130
- Diarrhoea 128
- Restlessness 127
- Accidental exposure 124
- Hyperactivity 92
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b10.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).