S-Adenosylmethionine — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-27. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. S-Adenosylmethionine (SAMe) is a hepatoprotective dietary supplement / liver-support agent.
Total reports
S-Adenosylmethionine: 384
Reports by species (top entries)
- Dog 371
- Cat 13
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 78
- Elevated alanine aminotransferase (ALT) 73
- Emesis 59
- Lethargy (see also Central nervous system depression in 'Neurological') 54
- Elevated serum alkaline phosphatase (SAP) 52
- Other abnormal test result NOS 51
- Elevated liver enzymes 43
- Diarrhoea 42
- Anorexia 33
- Death by euthanasia 28
- Weight loss 27
- Elevated total bilirubin 26
- Not eating 26
- Behavioural disorder NOS 25
- Elevated gamma-glutamyl transferase (GGT) 23
Source JSON: pdf-raw/ade/ade_s_adenosylmethionine_20260727.json (openFDA animalandveterinary/event.json, pulled 2026-07-27).