{"topic_id":"ade_s_adenosylmethionine_adverse_events","category":"ade","context":"---\ntopic_id: ade_s_adenosylmethionine_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for S-Adenosylmethionine (SAMe; hepatoprotective supplement / liver-support agent) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-27\"\nsource_file: pdf-raw/ade/ade_s_adenosylmethionine_20260727.json\ndate_parsed: 2026-07-27\ntokens_estimated: 240\nverification:\n  method: substring_match\n  claims: 36\n  passed: 36\n  date: 2026-07-27\nsource_document: \"FDA FAERS / openFDA Animal & Veterinary Event Reports\"\ncitation:\n  authority: \"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)\"\n  title: \"FDA ADE reports for S-Adenosylmethionine (SAMe; hepatoprotective supplement / liver-support agent) — total reports, species & reaction breakdown\"\n  url: \"\"\n  retrieved: \"2026-07-27\"\n  ref: \"\"\n  doc_type: \"open dataset (JSON API)\"\n  needs_review: true\n---\n# S-Adenosylmethionine — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-27. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. S-Adenosylmethionine (SAMe) is a hepatoprotective dietary supplement / liver-support agent.\n\n## Total reports\nS-Adenosylmethionine: 384\n\n## Reports by species (top entries)\n- Dog 371\n- Cat 13\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Vomiting 78\n- Elevated alanine aminotransferase (ALT) 73\n- Emesis 59\n- Lethargy (see also Central nervous system depression in 'Neurological') 54\n- Elevated serum alkaline phosphatase (SAP) 52\n- Other abnormal test result NOS 51\n- Elevated liver enzymes 43\n- Diarrhoea 42\n- Anorexia 33\n- Death by euthanasia 28\n- Weight loss 27\n- Elevated total bilirubin 26\n- Not eating 26\n- Behavioural disorder NOS 25\n- Elevated gamma-glutamyl transferase (GGT) 23\n\nSource JSON: `pdf-raw/ade/ade_s_adenosylmethionine_20260727.json` (openFDA animalandveterinary/event.json, pulled 2026-07-27).\n","sources":["US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database) — FDA ADE reports for S-Adenosylmethionine (SAMe; hepatoprotective supplement / liver-support agent) — total reports, species & reaction breakdown (retrieved 2026-07-27)"],"source":{"authority":"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)","title":"FDA ADE reports for S-Adenosylmethionine (SAMe; hepatoprotective supplement / liver-support agent) — total reports, species & reaction breakdown","url":"https://open.fda.gov/data/animal-and-veterinary/","retrieved":"2026-07-27","ref":"","doc_type":"open dataset (JSON API)","source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","verification_file":"pdf-raw/ade/ade_s_adenosylmethionine_20260727.json"},"source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","source_file":"pdf-raw/ade/ade_s_adenosylmethionine_20260727.json","tokens_estimated":240,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}