Polysulfated Glycosaminoglycan — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Polysulfated Glycosaminoglycan is a PSGAG disease-modifying osteoarthritis agent (intra-articular, dogs).
Total reports
Polysulfated Glycosaminoglycan: 5761
Reports by species (top entries)
- Dog 3955
- Horse 415
- Cat 312
- Human 27
- Other Birds 7
- Other 6
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 1065
- Diarrhoea 763
- Product Defect, General 595
- Lack of efficacy - NOS 572
- Lethargy (see also Central nervous system depression in 'Neurological') 526
- Not eating 380
- Death by euthanasia 296
- Color, Abnormal 267
- Lethargy (see also Central nervous system depression in Neurological) 245
- Elevated alanine aminotransferase (ALT) 238
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).