{"topic_id":"ade_polysulfated_glycosaminoglycan_adverse_events","category":"ade","context":"---\ntopic_id: ade_polysulfated_glycosaminoglycan_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for Polysulfated Glycosaminoglycan (PSGAG disease-modifying osteoarthritis agent (intra-articular, dogs)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-22\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json\ndate_parsed: 2026-07-22\ntokens_estimated: 216\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-22\n---\n\n# Polysulfated Glycosaminoglycan — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Polysulfated Glycosaminoglycan is a PSGAG disease-modifying osteoarthritis agent (intra-articular, dogs).\n\n## Total reports\nPolysulfated Glycosaminoglycan: 5761\n\n## Reports by species (top entries)\n- Dog 3955\n- Horse 415\n- Cat 312\n- Human 27\n- Other Birds 7\n- Other 6\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Vomiting 1065\n- Diarrhoea 763\n- Product Defect, General 595\n- Lack of efficacy - NOS 572\n- Lethargy (see also Central nervous system depression in 'Neurological') 526\n- Not eating 380\n- Death by euthanasia 296\n- Color, Abnormal 267\n- Lethargy (see also Central nervous system depression in Neurological) 245\n- Elevated alanine aminotransferase (ALT) 238\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json` (openFDA animalandveterinary/event.json, pulled 2026-07-22).\n","sources":[],"tokens_estimated":297,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}