Lufenuron — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Lufenuron is a insect development inhibitor (flea).
Total reports
Lufenuron: 39711
Reports by species (top entries)
- Dog 36594
- Cat 1148
- Human 108
- Ferret 3
- Other 3
- Goat 2
Top reported reactions (VEDDRA terms, top entries)
- INEFFECTIVE, HEARTWORM LARVAE 5705
- Vomiting 5631
- Lack of efficacy (endoparasite) - hookworm 4233
- Lack of efficacy (endoparasite) - heartworm 3523
- Diarrhoea 3146
- INEFFECTIVE, ASCARIDS NOS 2000
- Lethargy (see also Central nervous system depression in 'Neurological') 1917
- INEFFECTIVE, HOOKS 1869
- Lack of efficacy - NOS 1371
- Depression 1343
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).