{"topic_id":"ade_lufenuron_adverse_events","category":"ade","context":"---\ntopic_id: ade_lufenuron_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for Lufenuron (insect development inhibitor (flea)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 208\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-21\n---\n\n# Lufenuron — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Lufenuron is a insect development inhibitor (flea).\n\n## Total reports\nLufenuron: 39711\n\n## Reports by species (top entries)\n- Dog 36594\n- Cat 1148\n- Human 108\n- Ferret 3\n- Other 3\n- Goat 2\n\n## Top reported reactions (VEDDRA terms, top entries)\n- INEFFECTIVE, HEARTWORM LARVAE 5705\n- Vomiting 5631\n- Lack of efficacy (endoparasite) - hookworm 4233\n- Lack of efficacy (endoparasite) - heartworm 3523\n- Diarrhoea 3146\n- INEFFECTIVE, ASCARIDS NOS 2000\n- Lethargy (see also Central nervous system depression in 'Neurological') 1917\n- INEFFECTIVE, HOOKS 1869\n- Lack of efficacy - NOS 1371\n- Depression 1343\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":208,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}